SH2 domain

(redirected from Src homology 2 domain)

SH2 domain

A modular, circa-100-amino acid domain which binds to specific phospho-containing peptide motifs; SH2 is found in adaptors, kinases, phosphatase, Ras signalling, scaffolds, transcription, ubiquination. It is involved in cytoskeletal regulation, phospholipid second messenger signalling, and in signal regulation.
References in periodicals archive ?
In this collection of 11 articles, contributors describe their work in PTKs in such areas as using PTKs as targets for cancer and other indications, targeting Src homology 2 domains in drug discovery, using P12-kinase inhibition as a target for therapeutic intervention, using an activated FLT3 receptor tyrosine kinase as a therapeutic target in leukemia and JAK kinases in leukemia, lymphomas and multiple myeloma, applying platelet-derived growth factor, using a targeted therapy for myelogenous leukemia, testing signal transduction inhibitors in animal models of cancer, and using phosphoproteomics in drug discovery and development.