Ornskov, "Evaluation of p16INK4a/Ki-67 dual stain in comparison with an mRNA human papillomavirus test on liquid-based cytology samples with low-grade squamous intraepithelial lesion
," Cancer Cytopathology, vol.
Using a low threshold reference standard of cytology diagnosed squamous intraepithelial lesion
and the HIV status of the women masked, VIA and VILI had similar test characteristics except for the PPV in which VIA value of 91.5% was significantly higher than 77.7% for VILI (p=0.01).
Incidence of cervical squamous intraepithelial lesions
in HIV-infected women.
Infection with the human immunodeficiency virus (HIV) and its related immunosuppression are associated with an increased risk of prevalence, incidence, and persistent squamous intraepithelial lesions
(SILs) of the cervix (2, 3).
Among the positive findings were 12 cases of atypical squamous cells of undetermined significance (5.2%), 28 low-grade squamous intraepithelial lesions
(12%), 1 high-grade squamous intraepithelial lesion
(0.4%) and 2 cases of cancer (0.9%).
This 2-year prospective study examined a subpopulation of 1539 women from the ASCUS/LSIL (atypical squamous cells of uncertain significance)/Bow-grade squamous intraepithelial lesion
) Triage Study (ALTS) to determine the ideal follow-up strategy for women diagnosed with CIN1 or HPV effect on colposcopic biopsy-obtained histology.
A review and update on papillary immature metaplasia of the uterine cervix: a distinct subset of low-grade squamous intraepithelial lesion
, proposing a possible cell of origin.
Caption: Figure 1: (a) Atypical cells of undetermined significance, (b) low-grade squamous intraepithelial lesion
, (c) high-grade squamous intraepithelial lesion
, (d) squamous cell carcinoma, (e) changes of herpes simplex virus, and (f) human papillomavirus--koilocytic changes
34 cases (5.63%) showed squamous intraepithelial lesion
Since women with cytology results of low-grade squamous intraepithelial lesion
(LSIL) progress to CIN 2 or 3 in the same proportion, management protocols for HPV-positive ASCUS and LSIL should be identical.
In our cytopathology laboratory, the specimens are prepared via ThinPrep methodology (Cytyc) and interpreted by using the Bethesda system terminology as unsatisfactory; benign; ASC-US; low-grade squamous intraepithelial lesion
(LSIL); atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion
(ASC-H); HSIL; and squamous cell carcinoma (SCC).
Atypical Squamous cells cannot exclude a HSIL (ASC-H) (n=24/0.19%), Low Grade Squamous Intraepithelial Lesion
(LSIL) (n=172/1.35%), High Grade Squamous Intraepithelial Lesion
(HSIL) (n=91/17.3%) Squamous cell carcinoma (n=21/0.17%) Atypical Glandular Cells (AGC-NOS) (n=53/0.42%) Atypical Glandular Cells--favor neoplastic (n=23/0.18%) Endocervical adenocarcinoma in situ (n=01/ 0.01%) Endocervical adenocarcinoma (n=01/0.01%) Endometrial adenocarcinoma (n=19/0.15%).