Squamous intraepithelial lesion

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squamous intraepithelial lesion

Cytology A term that encompasseses a spectrum of noninvasive cervical epithelial abnormalities–eg, flat condyloma, dysplasia/carcinoma in situ, CIN; the Bethesda Classification divides SILs into low-grade and high-grade lesions; the former encompass cellular changes associated with HPV cytopathic effect–koilocytotic atypia and mild dysplasia; high-grade lesions encompass moderate dysplasia, severe dysplasia, carcinoma in situ/CIN2–3. See CIN, High-grade squamous intraepithelial lesion, Low-grade squamous intraepithelial lesion, Pap smear.

Squamous intraepithelial lesion (SIL)

A term used to categorize the severity of abnormal changes arising in the squamous, or outermost, layer of the cervix.
Mentioned in: Cervical Cancer, Pap Test
References in periodicals archive ?
Because the ASCUS to squamous intraepithelial lesion ratio (ASCUS:SIL ratio) has much less variability than the ASCUS rate, this monitor is more useful for interlaboratory comparisons, such as in benchmarking.
A number of alternatives and enhancements for prospective rescreening have been proposed, including rapid prescreening/rescreening, enriching the random rescreen sample with known squamous intraepithelial lesion (SIL) cases, 100% rescreening of NILM Pap tests, sharing cases among laboratories, and automated quality control slide selection.
ASC will consist of two types: those of undetermined significance (ASC-US) and those with cytologic changes suggestive of high-grade squamous intraepithelial lesions (HSIL) that lack definitive criteria (ASC-H).
Atypical squamous cells, cannot exclude a high-grade squamous intraepithelial lesion and its clinical significance in postmenopausal, pregnant, postpartum, and contraceptive-use patients.
At our institution, most high-grade squamous intraepithelial lesions (HSILs) corresponding to cervical intraepithelial neoplasia (CIN) II and III are treated by loop electrosurgical excision procedure (LEEP).
Sherman ME, Schiffman M, Cox JT; Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study Group.
Stoler MH, Schiffman M; Atypical Squamous Cells of Undetermined Significance-Low-grade Squamous Intraepithelial Lesion Triage Study Group.
The result is presented using two reference threshold of: low threshold of cytology diagnosed squamous intraepithelial lesion or high threshold of cytology diagnosed high grade intraepithelial lesion or worse lesion.
Immunohistochemical expression of granzyme B and vascular endothelial growth factor (VEGF) in normal uterine cervices and low and high grade squamous intraepithelial lesions," European Journal Gynaecological Oncology, vol.
More than half of the women (55%) had a record of low-grade squamous intraepithelial lesions (LSIL), which may develop into high-grade lesions and eventually result in cervical cancer.
In another study done by Khan and his colleagues the percentage of lowgrade squamous intraepithelial lesion was 3.