squalene synthase

squa·lene syn·thase

an enzyme that catalyzes the formation of squalene from two molecules of farnesylpyrophosphate using NADPH and concomitant production of two molecules of pyrophosphate.
References in periodicals archive ?
Quach et al., "Molecular characterization of Glycine max squalene synthase genes in seed phytosterol biosynthesis," Plant Physiology and Biochemistry, vol.
Acetyl CoA: acetyl coenzyme A; HMG-CoA: hydroxymethyl glutaryl coenzyme A; IPP: isopentenyl diphosphate; SQS: squalene synthase; DXP: desoxicelulose 5-phosphate; DXS: desoxicelulose 5-phosphate synthase; IDI: isopentenyl diphosphate isomerase; IDS: isopentenyl diphosphate synthase; FPS: farnesyl diphosphate synthase; GPP: geranyl diphosphate; HSQS: hydrosqualene.
In another study, recombinant cell lines were generated by overexpressing a key sterol biosynthetic pathway gene (Squalene synthase) of W.
coagulans, transformed hairy roots were produced which overproduced squalene synthase SS1 gene from A.
Therefore, the present study was designed to investigate the expression of key enzymes of mevalonate pathway in (1) aortas from streptozotocin- (STZ-) induced 0-, 8-, and 16-week diabetic mice in vivo and (2) high-glucose-induced proliferated VSMCs in vitro, including HMGR, FPPS, FNT-[beta], GGT-1[beta], squalene synthase (SQS), phosphor-3-hydroxy-3-methylglutaryl- coenzyme A reductase (P-HMGR), and geranylgeranyl pyrophosphate synthase (GGPPS) (Figure 1).
We also checked expression of FDFT1 (gene encoding squalene synthase, first enzyme of cholesterol synthesis) and found it to be up regulated in ALN treated cells.
Squalene synthase acts more distally than HMGCoA-reductase (the target of statins) in the biosynthesis of cholesterol.
Another non-alkaloidal enzyme, squalene synthase, was also partially purified from a membrane-rich fraction obtained from cell suspension cultures of T.
Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro.
Lanosterot 14alpha-demethylase (CYP51), NADPH-cytochrome P450 reductase and squalene synthase in spermatogenesis: late spermatids of the rat express proteins needed to synthesize follicular fluid meiosis activating sterol.
To thwart this protozoan, researchers have targeted squalene synthase, an enzyme that T.
10 thaliana [AC002986] AA525686 germin like protein [U75205] 19 AA525688 aspartic proteinase precursor [P42211] 58 AA525692 unknown protein [AC004122] 27 AA525697 pectin methylesterase [Y08155] 34 AA577634 farnesyl-diphosphate farnesyltransferase 30 (squalene synthase) [JC5031] AA577635 cellulase homolog OR16pep [S71215] 15 AA577636 contains similarity to S.