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disease of the joints of the spine.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Any of several diseases of the joints of the spine.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

Patient discussion about spondyloarthropathy

Q. Our GP said that I have a greater risk for joint disease because I am HLA-B27 + . what is he talking about? My mom and dad have a spondyloarthropathy. they went to our GP and he did us some genetic tests and said that I am HLA-B27 positive, and that i have a greater risk for several diseases. what kind of diseases is he talking about?

A. HLA-B27 is a part of our immune system. Some of us )like me) have this gene and some of us don't have it. The fact you have this gene says you might have some diseases.
Those diseases are mainly arthritis for its kinds and inflammatory bowel diseases (witch I have and its totally manageable.
if your parents have only spondyloarthropathy I guess you can expect you will have a spondyloarthropathy too.
Go to your GP and ask him to explain you more about this.

More discussions about spondyloarthropathy
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References in periodicals archive ?
Efficacy of tumour necrosis factor blockers in reducing uveitis flares in patients with spondylarthropathy: a retrospective study.
The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy.
Use of dynamic magnetic resonance imaging with fast imaging in the detection of early and advanced sacroiliitis in spondylarthropathy patients.
Egeberg and his coauthors reported that HS and inflammatory bowel disease similarities suggest a shared pathogenesis, including the worsening effect of smoking on both conditions; the appearance of scarring and sinus tract formation; the apparent involvement of T-helper 17 cells, interleukin-23, and tumor necrosis factor; and the coinvolvement of genes such as SULT1B1 and SULT1 E1 "Finally, an increased prevalence of spondylarthropathy has been reported in patients with IBD as well as in those with HS, raising the hypothesis that genetic, epigenetic, and/or environmental factors cooperate to lead to dysregulated inflammatory pathways across these immune-mediated diseases," they wrote.
Juhlin et al., "The European spondylarthropathy study group preliminary criteria for the classification of spondylarthropathy," Arthritis and Rheumatism, vol.
Breban, "Recurrence of spondylarthropathy among firstdegree relatives of patients: A systematic cross-sectional Study," Annals of the Rheumatic Diseases, vol.
High frequency of silent inflammatory bowel disease in spondylarthropathy. Arthritis Rheum.
Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down-regulation by tumor necrosis factor alpha blockade in spondylarthropathy. Arthritis Rheum 2004; 50:2942-53.
Late onset spondylarthropathy: clinical and biological comparison with early onset patients.
Anti-tumor necrosis factor [alpha] blockade in the treatment of juvenile spondylarthropathy. Arthritis Rheum 2005; 52: 2103-8.
Magnetic resonance imaging of sacroiliitis in early seronegative spondylarthropathy. Abnormalities correlated to clinical and laboratory findings Rheumatology 2004; 43: 234- 237.