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disease of the joints of the spine.


Any of several diseases of the joints of the spine.

Patient discussion about spondyloarthropathy

Q. Our GP said that I have a greater risk for joint disease because I am HLA-B27 + . what is he talking about? My mom and dad have a spondyloarthropathy. they went to our GP and he did us some genetic tests and said that I am HLA-B27 positive, and that i have a greater risk for several diseases. what kind of diseases is he talking about?

A. HLA-B27 is a part of our immune system. Some of us )like me) have this gene and some of us don't have it. The fact you have this gene says you might have some diseases.
Those diseases are mainly arthritis for its kinds and inflammatory bowel diseases (witch I have and its totally manageable.
if your parents have only spondyloarthropathy I guess you can expect you will have a spondyloarthropathy too.
Go to your GP and ask him to explain you more about this.

More discussions about spondyloarthropathy
References in periodicals archive ?
Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondylarthropathies. J Immunol 1999; 163: 6665-70.
(28.) Clegg DO, Reda DJ, Abdellatif M.Comparison of sulfasalazine and placebo for the treatment of axial and peripheral articular manifestations of the seronegative spondylarthropathies: a Department of Veterans Affairs cooperative study.
Nerve growth factor (NGF) autoantibodies and NGF in the synovial fluid: implications in spondylarthropathies. Autoimmunity 24:1-9.
AS is a member of the family of diseases that attack the spine called spondylarthropathies. In addition to AS, these diseases include Reiter's syndrome, some cases of psoriatic arthritis and the arthitis of inflammatory bowel disease.
HLA-B27 subtypes in the spondylarthropathies. Clin Exp Immunol 1993;91:214-9.
Just last year, 17 years after the strong association between HLA-B27 and ankylosing spondylitis was discovered, two Texas researchers confirmed the central role of HLA-B27 in the family of diseases called spondylarthropathies, which includes ankylosing spondylitis, Reiter's syndrome, psoriatic spondylitis and acute anterior uvertis, or iritis.
Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity.
Nurmohamed, "Cardiovascular risk profile of patients with spondylarthropathies, particularly ankylosing spondylitis and psoriatic arthritis," Seminars in Arthritis and Rheumatism, vol.
Late-onset ankylosing spondylitis and related spondylarthropathies: clinical and radiological characteristics and pharmacological treatment options.
Siakka et al., "Low dose of infliximab is inadequate in most patients with spondylarthropathies," Clinical and Experimental Rheumatology, vol.
Monteleone, "Common immunologic mechanisms in inflammatory bowel disease and spondylarthropathies," World Journal of Gastroenterology, vol.
The first successful experiments reproducing human arthritic diseases collectively called spondylarthropathies in laboratory animals were recently reported by Dr.