SF3B4

SF3B4

A gene on chromosome 1q21.2 that encodes subunit 4 of the splicing factor SF3B, which is required for “A” complex assembly by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. It may anchor U2 snRNP to pre-mRNA and be involved in the assembly of the “E” complex. SF3B4 is also found in complexes B and C and belongs to the U12-dependent spliceosome, which is involved in splicing the nuclear pre-mRNA intron.