In most cases, the histologic differential diagnosis was between Spitz nevus
and spitzoid melanoma or between atypical nevus (such as variants of deep penetrating/clonal/inverted type-A nevus, pigmented spindle cell nevus, atypical genital nevus, atypical conjunctival nevus showing cytologic atypia, mitotic activity, limited maturation, or proliferative nodules, among others) and nevoid melanoma (Table 1).
They revealed that PHH3 expression was higher in malignant melanomas, averaging 25/10HPF than in Spitz nevus
, averaging 0.
Lesions included adnexal neoplasm, ameloblastic fibro-odontoma, basal cell carcinoma, benign fibrous histiocytoma, blue nevus, chondrosarcoma, compound nevus, epithelioma adenoides cysticum, esthesioneuroblastoma, Ewing sarcoma, fibrosarcoma, giant cell granuloma, granulocytic sarcoma, hemangioma, hemangiopericytoma, Langerhans cell histiocytosis, lymphangioma, lymphoma, melanoma, neuroblastoma, neurofibroma, ossifying osteofibroma, osteochondroma, osteosarcoma, port wine stain, rhabdomyosarcoma, Spitz nevus
, and xanthogranuloma.
cogunlukla cocuk ve adolesanlarda gorulen, benin, genellikle edinsel melanositik tumordur.
The most common scenarios in melanoma litigation cases include nodular melanoma being misdiagnosed by a clinician or pathologist, a partial biopsy not capturing the most diagnostically relevant part of the lesion, malignant melanoma being misdiagnosed as a dysplastic or spitz nevus
, unrecognized desmoplastic malignant melanoma, and metastatic malignant melanoma with an unknown primary or recurrence of melanoma (Am.
Spitzoid lezyonlar, bir ucunda Spitz nevus
, diger ucunda ise Spitzoid melanom, arada ise atipik Spitz nevus
, atipik Spitzoid tumor veya malignite potansiyeli bilinmeyen Spitzoid tumor (Spitzoid tumor of uncertain malignant potential, STUMP) olarak degisik sekillerde isimlendirilen hem Spitz nevus
hem de melanomun ozelliklerini tasiyan vakalarin bulundugu bir spektrum olarak kabul edilebilir (8).
We report a woman with a hyalinizing Spitz nevus
and review the clinical characteristics, histologic features, and differential diagnosis of this lesion.
is a well-known mimicker of melanoma, although Dr.
Subsequent studies showed that the large bulky Spitz nevi, with sclerotic changes at the base, were morphologically the most likely type of Spitz nevus
to carry this isolated gain in 11p.
30,31) Another study of 3 Spitz nevi and 2 spitzoid melanomas, using aCGH, showed that 1 Spitz nevus
had a gain of 11p, while the other 2 Spitz nevi exhibited no significant chromosomal aberrations.
The most challenging diagnosis is the subtype spitzoid melanoma (SM), which clinically and histopathologically resembles Spitz nevus
28) It is usually associated with a common compound or dermal nevus, or, much less frequently, Spitz nevus