In most cases, the histologic differential diagnosis was between
Spitz nevus and spitzoid melanoma or between atypical nevus (such as variants of deep penetrating/clonal/inverted type-A nevus, pigmented spindle cell nevus, atypical genital nevus, atypical conjunctival nevus showing cytologic atypia, mitotic activity, limited maturation, or proliferative nodules, among others) and nevoid melanoma (Table 1).
They revealed that PHH3 expression was higher in malignant melanomas, averaging 25/10HPF than in
Spitz nevus, averaging 0.
Lesions included adnexal neoplasm, ameloblastic fibro-odontoma, basal cell carcinoma, benign fibrous histiocytoma, blue nevus, chondrosarcoma, compound nevus, epithelioma adenoides cysticum, esthesioneuroblastoma, Ewing sarcoma, fibrosarcoma, giant cell granuloma, granulocytic sarcoma, hemangioma, hemangiopericytoma, Langerhans cell histiocytosis, lymphangioma, lymphoma, melanoma, neuroblastoma, neurofibroma, ossifying osteofibroma, osteochondroma, osteosarcoma, port wine stain, rhabdomyosarcoma,
Spitz nevus, and xanthogranuloma.
Spitz nevus cogunlukla cocuk ve adolesanlarda gorulen, benin, genellikle edinsel melanositik tumordur.
The most common scenarios in melanoma litigation cases include nodular melanoma being misdiagnosed by a clinician or pathologist, a partial biopsy not capturing the most diagnostically relevant part of the lesion, malignant melanoma being misdiagnosed as a dysplastic or
spitz nevus, unrecognized desmoplastic malignant melanoma, and metastatic malignant melanoma with an unknown primary or recurrence of melanoma (Am.
Spitzoid lezyonlar, bir ucunda
Spitz nevus, diger ucunda ise Spitzoid melanom, arada ise atipik
Spitz nevus, atipik Spitzoid tumor veya malignite potansiyeli bilinmeyen Spitzoid tumor (Spitzoid tumor of uncertain malignant potential, STUMP) olarak degisik sekillerde isimlendirilen hem
Spitz nevus hem de melanomun ozelliklerini tasiyan vakalarin bulundugu bir spektrum olarak kabul edilebilir (8).
We report a woman with a hyalinizing
Spitz nevus and review the clinical characteristics, histologic features, and differential diagnosis of this lesion.
Spitz nevus is a well-known mimicker of melanoma, although Dr.
Subsequent studies showed that the large bulky Spitz nevi, with sclerotic changes at the base, were morphologically the most likely type of
Spitz nevus to carry this isolated gain in 11p.
30,31) Another study of 3 Spitz nevi and 2 spitzoid melanomas, using aCGH, showed that 1
Spitz nevus had a gain of 11p, while the other 2 Spitz nevi exhibited no significant chromosomal aberrations.
The most challenging diagnosis is the subtype spitzoid melanoma (SM), which clinically and histopathologically resembles
Spitz nevus.
28) It is usually associated with a common compound or dermal nevus, or, much less frequently,
Spitz nevus.
