SPINK1

(redirected from Spink3)

SPINK1

A gene on chromosome 5q32 that encodes a trypsin inhibitor secreted from pancreatic acinar cells into pancreatic juice. SPINK1 is thought to prevent trypsin-catalysed premature activation of zymogens within the pancreas and the pancreatic duct.

Molecular pathology
SPINK1 mutations are associated with hereditary pancreatitis and tropical calcific pancreatitis.
References in periodicals archive ?
In a carcinogen-induced colitis and colon cancer mouse model, expression levels of SPINK3, the mouse ortholog of SPINK1, correlated with colitis and subsequent tumor burden, suggesting a link between SPINK3 and inflammation-induced colon cancer (56).