Age- and sex-dependent change in stratum corneum sphingolipids
. Arch Dermatol Res.
These metabolites belong to the categories of glycerophospholipids, sphingolipids
, steroids and fatty acids, which were involved into glycerophospholipid metabolism, sphingolipid
metabolism, fatty acid [beta]-oxidation pathway and bile acid biosynthesis.
Riganti et al., "Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid
metabolism," EMBO Journal, vol.
A complex aspect of the "sphingolipid
rheostat" is that ceramide can be converted to other sphingolipids
with signalling properties.
In preliminary clinical studies, the technology demonstrated significantly better barrier function with substantial improvement in moisture retention when compared to commercially available sphingolipid
Discovery of the GlcCer-deficient cells and subsequent success in the molecular cloning of the GlcCer synthase gene triggered my research interest to re-focus metabolism and functions of common, basic, and simple sphingolipids
instead of studying complex GSLs.
Their product line includes a broad range of sphingolipids
, glycolipids, glycosphingolipids, fatty acids and esters, sterols, and vitamin E isomers (tocopherols and tocotrienols).
They looked specifically at acylcarnitines, phospholipids, lysophospholipids, and sphingolipids
. They found that phospholipids were elevated in schizophrenia patients, compared with controls, and even more elevated in patients with bipolar disorder.
The toxicity can be explained by differences in sphingolipids
, especially glycosylphosphatidyl inositol, present in the plasma membranes of both types of plants.
Within the refined profile, five clusters of metabolites emerged with prominent subpathways, including known mediators of lung disease such as sphingolipids
(elevated in cases of WTC-LI), and branched-chain amino acids (reduced in cases of WTC-LI).
Deficient activity of N-acetylglucosamine-1-phosphotransferase leads to defective posttranslational modification of lysosomal enzymes, promoting the intracellular accumulation of both partly degraded glycosaminoglycans and sphingolipids
. (1-3) The trafficking process that transports the lysosomal enzymes to the interior of lysosomes is impaired.
are essential structural components of all cell membranes and highly bioactive compounds that play important roles in signal transduction and numerous other cellular processes such as cell proliferation, differentiation, and apoptosis.