Speckled Pattern

Imaging Image texture The background ‘canvas’ on which different echoes in an ultrasonogram are painted
Rheumatology An immunofluorescence pattern that may be seen when the human epithelial cell line, HEp-2, is stained with serum from patients with connective tissue diseases, especially SLE, but also mixed connective tissue disease (MCTD), sicca syndrome, Sjögren syndrome, polymyositis, rheumatoid arthritis, and drug-induced immune reactions
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
(7) evaluated FAF patterns in early AMD patients and the most common pattern was speckled pattern (26%) followed by patchy pattern (23%).
Previously, our laboratory reported articles focusing on 4-year ANA results (2), and frequency of dense fine speckled pattern (3).
The following immunofluorescence patterns were observed: nuclear fine speckled pattern (37.7%); nuclear dense fine speckled (18.9%); mixed patterns (18.9%); nuclear large/coarse speckled (9.4%); nuclear homogeneous (7.8%); cytoplasmic (7.5%); nucleolar (1.9%); and mitotic apparatus (1.9%).
Application of anti-DFS70 antibody and specific autoantibody test algorithms to patients with the dense fine speckled pattern on Hep-2 cells.
Figure 2(b) presents an enlarged image of the speckled pattern over an area of approximately 50 mm square.
It was found that 16 samples had a speckled pattern (57%), 8 were homogeneous (29%), and 3 had other patterns (11%).
Later in 1963 during a study on 120 patients of DLE, Rowell found distinct clinical and serological findings in 4 female patients having EM-like lesions, positive RF, positive anti-SjT (analogous to anti-Ro/La antibody) and speckled pattern of ANA.1 Most consistent serological finding is speckled ANA (90%) and least are serum RF and anti-SjT or anti-Ro/La antibody.
Then the part is cut off of the build plate and re-imaged with the projected speckled pattern.
The laboratory data revealed elevation of aspartate transaminase 1019 U/L (normal: 10-40 U/L), alanine transaminase 235 U/L (normal: 10-55 U/L), total bilirubin 7.2 mg/dL (normal: 0.0-1.0 mg/dL), direct bilirubin 5.3 mg/dL (normal: 0.0-0.4 mg/dL), creatine kinase 1489 U/L (normal: 60-400 U/L), positive at 1:640 dilutions of antinuclear antibodies (ANAs) in speckled pattern (normal: <1:40), complement 3 level 19.0 mg/dL (normal: 86-184 mg/dL) and complement 4 level 6.9 mg/dL (normal: 20-58 mg/dL).
The most frequent ANA patterns were coarse speckled pattern (154 patients, 31.2%), nucleolar pattern (89 patients, 18.0%), fine speckled pattern (57 patients, 11.5%), and speckled pattern (48 patients, 9.7%).
Unless you are someone who carries a bottle of glass cleaner in a holster on your belt, you will see a speckled pattern. Depending on how vigilant you are, what you are looking at is a day, or a week, or in my case, several months' accumulation of sneezes.