(7) evaluated FAF patterns in early AMD patients and the most common pattern was speckled pattern
(26%) followed by patchy pattern (23%).
Previously, our laboratory reported articles focusing on 4-year ANA results (2), and frequency of dense fine speckled pattern
The following immunofluorescence patterns were observed: nuclear fine speckled pattern
(37.7%); nuclear dense fine speckled (18.9%); mixed patterns (18.9%); nuclear large/coarse speckled (9.4%); nuclear homogeneous (7.8%); cytoplasmic (7.5%); nucleolar (1.9%); and mitotic apparatus (1.9%).
Application of anti-DFS70 antibody and specific autoantibody test algorithms to patients with the dense fine speckled pattern
on Hep-2 cells.
Figure 2(b) presents an enlarged image of the speckled pattern
over an area of approximately 50 mm square.
It was found that 16 samples had a speckled pattern
(57%), 8 were homogeneous (29%), and 3 had other patterns (11%).
Later in 1963 during a study on 120 patients of DLE, Rowell found distinct clinical and serological findings in 4 female patients having EM-like lesions, positive RF, positive anti-SjT (analogous to anti-Ro/La antibody) and speckled pattern
of ANA.1 Most consistent serological finding is speckled ANA (90%) and least are serum RF and anti-SjT or anti-Ro/La antibody.
Antinuclear antibody (ANA, speckled pattern
, 1:160), anti-dsDNA, and anti-SSA antibodies were positive.
Then the part is cut off of the build plate and re-imaged with the projected speckled pattern
The laboratory data revealed elevation of aspartate transaminase 1019 U/L (normal: 10-40 U/L), alanine transaminase 235 U/L (normal: 10-55 U/L), total bilirubin 7.2 mg/dL (normal: 0.0-1.0 mg/dL), direct bilirubin 5.3 mg/dL (normal: 0.0-0.4 mg/dL), creatine kinase 1489 U/L (normal: 60-400 U/L), positive at 1:640 dilutions of antinuclear antibodies (ANAs) in speckled pattern
(normal: <1:40), complement 3 level 19.0 mg/dL (normal: 86-184 mg/dL) and complement 4 level 6.9 mg/dL (normal: 20-58 mg/dL).
The most frequent ANA patterns were coarse speckled pattern
(154 patients, 31.2%), nucleolar pattern (89 patients, 18.0%), fine speckled pattern
(57 patients, 11.5%), and speckled pattern
(48 patients, 9.7%).
Unless you are someone who carries a bottle of glass cleaner in a holster on your belt, you will see a speckled pattern
. Depending on how vigilant you are, what you are looking at is a day, or a week, or in my case, several months' accumulation of sneezes.