hereditary spastic paraplegia

(redirected from Spastic ataxia)

hereditary spastic paraplegia

Any of a group of inherited diseases of the central nervous system characterized by muscle spasticity, esp. of the lower extremities.
Synonym: Troyer syndrome
See also: paraplegia
References in periodicals archive ?
In time, there might be significant recovery of the peripheral nerve function but, depending on the degree of pyramidal involvement, spastic ataxia may be a permanent outcome of severe OPIDP.
Interestingly, 1 of these alleles corresponded to a previously reported CNV (27,28), which was also detected in other samples analyzed in this study together with SACS point mutations, producing autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) (29, 30, 35).
Pseudodominant inheritance of spastic ataxia of Charlevoix-Saguenay.
An inherited large-scale rearrangement in SACS associated with spastic ataxia and hearing loss.
A novel genomic disorder: a deletion of the SACS gene leading to spastic ataxia of Charlevoix-Saguenay.
A spastic ataxia syndrome with prominent posterior column findings mimicking cobalamin deficiency (1) remains the archetypal and probably the most common neurologic presentation of copper deficiency.