sparfloxacin


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sparfloxacin

 [spahr-flok´sah-sin]
a synthetic, broad-spectrum antimicrobial agent.

sparfloxacin

/spar·flox·a·cin/ (spahr-flok´sah-sin) a synthetic, broad-spectrum antimicrobial agent.

sparfloxacin

an antiinfective.
indications It is used to treat community-acquired pneumonia and chronic bronchitis caused by Klebsiella pneumoniae, Haemophilus influenzae, H. parainfluenzae, and Moraxella catarrhalis.
contraindications Known hypersensitivity to quinolones and photosensitivity prohibit its use.
adverse effects Life-threatening effects are leukopenia and pseudomembranous colitis. Other adverse effects are eosinophilia, anemia, flatulence, diarrhea, QT interval prolongation, vasodilation, rash, pruritus, and photosensitivity. Common side effects are headache, dizziness, insomnia, nausea, vomiting, and abdominal pain.

sparfloxacin

Zagam® Infectious disease An advanced, broad-spectrum–gram-negative bacilli, staphylococci fluoroquinolone with improved activity against streptococci and anaerobes, TB, MAC Indications Community-acquired pneumonia, acute bacterial exacerbations of chronic bronchitis Adverse effects Photosensitivity, GI upset. See Fluoroquinolone.
References in periodicals archive ?
Significant increases in levofloxacin and sparfloxacin resistance were the most prominent (p<0.
He was seen by a local physician and was found to have abnormal liver function tests and was treated with sparfloxacin and silibinin.
cholerae, compared to ciprofloxacin, ofloxacin, sparfloxacin and levofloxacine in in vitro studies, suggesting that it can probably be used in the treatment of cholera caused by fluoroquinolone resistant strains of V.
The effect of reserpine an inhibitor of multidrug efflux pumps, on the in vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Staphylococcus aureus.
Norfloxacin and sparfloxacin as corrosion inhibitors for zinc.
Secretion of sparfloxacin from the human intestinal Caco-2 cell line is altered by P-glycoprotein inhibitors.
Grepafloxacin, sparfloxacin, moxifloxacin, and gatifloxacin are among the drugs commonly noted to cause QTc elongation.
Group B contains agents (clindamycin, gatifloxacin, levofloxacin, moxifloxacin, sparfloxacin, gemifloxacin, ofloxacin, tetracycline, and vancomycin) that warrant testing but can be reported selectively based on decisions made at your institution.
The fluoroquinolones that were used the most often in the studies were levofloxacin (Levaquin), sparfloxacin (Zagam), and moxifloxacin (Avelox).
The newer ones--such as lomefloxacin, sparfloxacin, and trovafloxacin--are better against anaerobes than the older ones.