SP1

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SP1

Abbreviation for stimulatory protein 1.

SP1

A gene on chromosome 12q13.1 that encodes a transcription factor  which up- or downregulates transcription in response to physiological and pathological stimuli. SP1 binds with high affinity to GC-rich motifs and regulates expression of an array of genes involved in various cell processes, including growth, differentiation, immune responses and apoptosis; it may have a role in modulating cell responses to DNA damage and is implicated in chromatin remodelling. SP1 is highly regulated by post-translational modification—e.g., phosphorylation, sumoylation, proteolytic cleavage, glycosylation and acetylation.
References in periodicals archive ?
Taken together, these data suggest the direct regulation of bovine Nanog proximal promoter activity by Sp1 transcription factor.
Our results demonstrate that the Sp1 transcription factor can regulate activation of the bovine Nanog promoter through direct binding to a Sp1-binding site within the proximal bovine promoter region.
The sections were immunostained for SP1 transcription factor to determine whether it was expressed in retinas exposed to AGEs.
SP1 transcription factor belongs to a group of factors that are associated with GC-rich promoters that are involved in basal promoter activity.
Eckert, "Involucrin expression in the corneal epithelium: an essential role for Sp1 transcription factors," Investigative Ophthalmology & Visual Science, vol.