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Related to Sotos: Sotos syndrome


J.F., 20th-century U.S. pediatrician. See: Sotos syndrome.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 5q35 that encodes a protein that  enhances androgen receptor transactivation, especially in the presence of other androgen receptor-associated coregulators. NSD1 acts as a nucleus-localised, basic transcriptional factor and as a bifunctional transcriptional regulator.

Molecular pathology
NSD1 mutations cause Sotos syndrome and Weaver syndrome, as well as a form of childhood acute myeloid leukaemia with a cryptic translocation, with breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, trithorax domain protein 1 on chromosome 5 and nucleoporin 98-kD on chromosome 11.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
* HEADING FOR THE FRONT: Holmfirth Harriers' David Turnbull (No 36) hits the comeback trail as he sets off from the start at the Sotos 10k in Fleetwood (s)
"My family is ecstatic that I'm here," said Soto during his time with Warriors@work in the Los Angeles area.
While at Fort Lewis, Soto took a trip home to Palmdale.
District's security officer, offered Soto the opportunity to be a part of the new Warriors@work program.
Due to his injury, Soto's initial work with the Corps consisted of filing and assisting office members with their paperwork.
Soto is always willing to complete whatever is required, and he's eager to learn about what we do here."
The work was not the only benefit to Soto. The flexible schedule allowed him to continue his treatment at a local medical facility.
Therefore, sleep apnea might explain why Taft--who weighed less and had an exemplary record in public service before and after his 4 years in the White House--is seen by many historians as a blunderer while president, Sotos says.