atorvastatin(redirected from Sortis)
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atorvastatin/ator·va·stat·in/ (ah-tor″vah-stat´in) an antihyperlipidemic agent that acts by inhibiting cholesterol synthesis, used as the calcium salt in the treatment of hypercholesterolemia and other forms of dyslipidemia.
A statin, (C33H34FN2O5)2Ca·3H2O, that blocks the body's synthesis of cholesterol and is used to treat hyperlipidemia.
indications This drug is used to lower the levels of both cholesterol and triglycerides in the plasma.
contraindications Known hypersensitivity, pregnancy, lactation, and active liver disease prohibit the use of this drug.
adverse effects Liver dysfunction is a potentially life-threatening side effect of this drug. Other adverse effects include rash, pruritus, alopecia, dyspepsia, flatus, pancreatitis, lens opacities, myalgia, and headache.
atorvastatinA cholesterol-lowering HMG-CoA reductase inhibitor, or statin, which improves the lipid profile—LDL-C reduced 35% to 60%; TGs reduced 20–37%; HDL-C increased 5–9%.
Liver dysfunction, rhabdomyolysis with acute renal failure secondary to myoglobinuria, constipation, flatulence, dyspepsia, abdominal pain, myalgia, weakness.
Homozygous familial hypercholesterolaemia, severe refractory hypercholesterolaemia.