SON

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SON

A gene on chromosome 21q22.11 that encodes an RNA-binding protein which acts as a mRNA splicing cofactor by promoting efficient splicing of cell cycle and DNA-repair transcripts (e.g., TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A and FANCG), which possess weak splice sites. SON also binds to DNA and may indirectly repress hepatitis-B virus (HBV) core promoter activity, as well as transcription of HBV genes and production of HBV virions.
References in periodicals archive ?
Ill-treated and stigmatised sonless women were found in this village as they were in many other villages of Asia where son preference prevails.
Today, bridgeless Mostar is full of ghosts: the bullet-holed facades and gutted buildings, the once vital young men whose faces hang from white markers in still graveyards, the sonless parents, heavy-eyed, who now inhabit a divided city.
Cumulatively, the denial of the right to inherit land, the stigma attached to childless divorcees, widows, sonless women and male control of access to the accrued sales from coffee, created conditions which may have accounted for the substantial migration of Ba-Haya women to urban areas to work as prost itutes.