SHH

(redirected from Sonic hedgehog)
Also found in: Acronyms, Wikipedia.

SHH

A gene on chromosome 7q36 that encodes a protein central in early embryonic patterning and the key inductive signal in patterning of the anterior-posterior limb axis, the ventral somites and the ventral neural tube.

Molecular pathology
Defects in SHH or in its signalling pathway cause holoprosencephaly, VACTERL syndrome; mutation upstream of SHH disrupts limb patterning and can result in preaxial polydactyly.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
En el caso del reconocimiento de la presencia de Sonic hedgehog (Shh) en las capas que constituyen el esbozo de iris, observamos que a los 17,5 dpc existe una inmunotincion positiva del morfogeno Shh en el primer segmento de la capa interna del iris.
The adventures of Sonic Hedgehog in development and repair.
Jessell, "Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity," Cell, vol.
Ruther, "Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development," Mechanisms of Development, vol.
Sonic Hedgehog myocardial gene therapy: Tissue repair through transient reconstitution of embryonic signaling.
Sonic Hedgehog is that signal, as we went on to demonstrate," Fuchs said.
Around the same time as the BBS result, Kathryn Anderson of Memorial Sloan-Kettering Cancer Center in New York City and colleagues were looking for genetic mutations that could scramble sonic hedgehog signals in mice.
Citation: "Persistent Sonic Hedgehog Signaling in Adult Brain Determines Neural Stem Cell Positional Identity;" Rebecca A.
In snake "gums," a gene called sonic hedgehog lays out the toothy part of the body plan.
One such example is "sonic hedgehog," a gene linked to holoprosencephaly.