SHH

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SHH

A gene on chromosome 7q36 that encodes a protein central in early embryonic patterning and the key inductive signal in patterning of the anterior-posterior limb axis, the ventral somites and the ventral neural tube.

Molecular pathology
Defects in SHH or in its signalling pathway cause holoprosencephaly, VACTERL syndrome; mutation upstream of SHH disrupts limb patterning and can result in preaxial polydactyly.
References in periodicals archive ?
Investigators reported that inhibiting mTORC1 disrupted the Sonic Hedgehog signaling pathway and significantly extended the lives of mice with the medulloblastoma that is driven by Sonic Hedgehog signaling.
The adventures of Sonic Hedgehog in development and repair.
Sonic Hedgehog is that signal, as we went on to demonstrate," Fuchs said.
Sonic hedgehog, it turns out, floats up to a cell and docks with another protein called Patchedl in a cilium's outer membrane.
Molecularly, the sonic hedgehog (Shh) (33) protein behaves like an intercellular signaling molecule, which is synthetized by a precursor that suffers self-catalytic reaction, (34) and both cholesterol and palmitic acid covalently adhere to Shh.
Cobras and vipers show extensive decay of the Sonic hedgehog limb enhancer, the researchers said.
Unlike two-headedness, this condition does not result from partially fused twins; it stems from problems early on in embryonic development connected to a protein signal called sonic hedgehog homolog, or SHH.
Washington, June 9 (ANI): Erectile dysfunction caused after the surgical removal of a cancerous prostate gland can be healed by a protein called sonic hedgehog, a new American study reveals.
NASDAQ: CRIS), a drug development company focused on seeking to develop novel targeted medicines primarily for cancer treatment, today announced that it was notified by one of its corporate partners, Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), that preliminary data with a protein agonist of the Sonic Hedgehog (Shh) signaling pathway showed promising results in an established, early preclinical cardiovascular animal model.
William Jeffery of the University of Maryland at College Park and his colleagues had previously reported that the gene sonic hedgehog controls eye and mouth formation in the freshwater fish Astyanax mexicanus.
NASDAQ: CRIS), a therapeutic drug development company, today announced the publication of preclinical data in the journal Circulation, showing that topical Sonic Hedgehog gene therapy accelerated wound healing in an animal model of diabetes.