Sonic Hedgehog Gene | definition of Sonic Hedgehog Gene by Medical dictionary
Sonic Hedgehog Gene
The vertebrate homologue of hedgehog, a Drosophilia—fruitfly—gene that ensures correct embryonic development. SHH products form a molecular gradient which determines which cells will emerge from the CNS during development. Toxins interfering with cholesterol metabolism in vertebrate embryos may cause cyclopia/holoprosencephaly. SHH is mutated in foetuses with holoprosencephaly type 3
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
Mutations in the human Sonic Hedgehog gene
The genetic change means the Sonic hedgehog gene
, which also controls the development of many organs, flickers only briefly when the embryo is only 24 hours old and then goes out at the point when limbs develop.
DISCUSSION: EMBRYOGENESIS: Notochord is not necessary for nephrogenesis but is required for correct positioning of the metanephric kidney, while the axial sonic hedgehog gene
signal is critical for kidney positioning along the mediolateral axis.
Among fish, functional enhancers occur in introns of the immunoglobulin gene of the channel catfish  and the sonic hedgehog gene
in ze Brafish .