Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Related to Sonata: sonata form, Zaleplon


trademark for a preparation of zaleplon, used to treat insomnia.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.



Pharmacologic class: Pyrazolopyrimidine, nonbenzodiazepine hypnotic

Therapeutic class: Sedative-hypnotic

Controlled substance schedule IV

Pregnancy risk category C


Binds to omega-1 receptor of gamma-aminobutyric acid receptor complex, relaxing smooth muscles, reducing anxiety, and producing sedation. Also has anticonvulsant effect.


Capsules: 5 mg, 10 mg

Indications and dosages


Adults younger than age 65: 10 mg P.O. at bedtime. Dosage above 20 mg is not recommended.

Dosage adjustment

• Mild to moderate hepatic impairment

• Elderly or debilitated patients


• Hypersensitivity to drug or its components


Use cautiously in:

• tartrazine sensitivity

• severe renal impairment (use not recommended), mild to moderate hepatic impairment, respiratory impairment, depression

• history of suicide attempt

• patients weighing less than 50 kg (110 lb)

• patients older than age 65

• pregnant or breastfeeding patients (use not recommended)

• children younger than age 18 (safety not established).


• Give at bedtime.

• Don't administer with high-fat meal.

Adverse reactions

CNS: headache, amnesia, anxiety, hallucinations, light-headedness, dizziness, drowsiness, depersonalization, transient memory or psychomotor impairment, incoordination, malaise, vertigo, asthenia, hyperesthesia, paresthesia, tremor

CV: peripheral edema

EENT: abnormal vision, eye pain, ear pain, hearing sensitivity, epistaxis

GI: nausea, abdominal pain, colitis, dyspepsia, anorexia

GU: dysmenorrhea

Musculoskeletal: myalgia

Skin: photosensitivity

Other: altered sense of smell, fever


Drug-drug. Cimetidine: decreased metabolism and increased effects of zaleplon

CNS depressants (including antihistamines, opioids, other sedative-hypnotics, phenothiazines, tricyclic antidepressants): additive CNS depression

CYP450-3A4 inducers (such as carbamazepine, phenobarbital, phenytoin, rifampin): decreased blood level and reduced efficacy of zaleplon

CYP450-3A4 inhibitors (such as erythromycin, ketoconazole): increased zaleplon blood level

Drug-food. High-fat meal: delayed drug absorption

Drug-herbs. Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors. Alcohol use: increased CNS depression

Patient monitoring

• Monitor drug efficacy. Insomnia persisting after 7 to 10 days warrants reevaluation for underlying psychological or physical illness.

• Stay alert for adverse drug reactions.

Patient teaching

• Explain therapy to patient. Emphasize importance of taking drug just before bedtime or after trying to sleep-but only if he will be able to get at least 4 hours of sleep.

• Inform patient that high-fat meal slows drug absorption and delays drug effects.

• Caution patient to avoid driving and other hazardous activities while under drug's influence.

• Instruct patient to avoid alcohol during therapy.

• Tell patient rebound insomnia may occur for 1 or 2 nights after he stops taking drug.

• Advise female of childbearing age to notify prescriber if she is or plans to become pregnant or if she is breastfeeding.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, foods, herbs, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A trademark for the drug zaleplon.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


Zaleplon Neurology A hypnotic GABAA–gamma-aminobutyric acid type A benzodiazepine receptor agonist for insomnia Adverse effects Headache, dizziness, somnolence. See Insomnia.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
A hallmark of the new Sonata's exterior is its Hyundai-first LED daytime running lights -- embedded in a chrome strip.
As Lee said, Hyundai Motor styled the new Sonata in quite a different way from its predecessors.
In sum, this history of the early keyboard sonata contains much solid and meticulous musicological work, and the most likely audience for the various chapters would be other specialists in the field.
Sonata is a global technology company that enables platform based digital transformation initiatives for enterprises, to create businesses that are connected, open, Intelligent and scalable.
Described as a comprehensive makeover of its predecessor that somewhat didn't see any major changes since 2015, the face-lifted Sonata is an adept family hauler that expresses proficient and distinctive gaze that could entice upwardly mobile executives and well-heeled officials as well as anyone with an eye for specifics.
We are thrilled to partner with Sonata Software and welcome them into our ecosystem."
Created at Hyundais California Design Studio, the 2018 Sonata builds on the models strong legacy, while distinctive new exterior styling transforms Sonatas visual signature.
Domenico Scarlatti is clearly the master composer of Italian keyboard sonatas. The three presented here are K.
"We are calling this, 'Sonata, the Reborn' because the changed look of the car is so radical, and represents such a big step in moving Hyundai's design credentials to the front of the market," said Hyundai's Head of Operations for Africa and the Middle East, Mike Song.
I dug the sportiness of the design but in the back of mind, I always thought of the Sonata as a model that has more to offer than just the looks.
This distinction continues to highlight Sonata's appeal to family buyers as it also recently won the, USA TODAY, MotorWeek Midsize Sedan Challenge and was also named the Best Midsize Car for the Money by US News & World Report.