SON


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SON

A gene on chromosome 21q22.11 that encodes an RNA-binding protein which acts as a mRNA splicing cofactor by promoting efficient splicing of cell cycle and DNA-repair transcripts (e.g., TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A and FANCG), which possess weak splice sites. SON also binds to DNA and may indirectly repress hepatitis-B virus (HBV) core promoter activity, as well as transcription of HBV genes and production of HBV virions.
References in classic literature ?
1-13) `Peleus the son of Aeacus, dear to the deathless gods, came to Phthia the mother of flocks, bringing great possessions from spacious Iolcus.
83: Some write `Serus the son of Halirrhothius', whom Hesiod mentions: `He (begot) Serus and Alazygus, goodly sons.
7: This oracle most clearly proves that Asclepius was not the son of Arsinoe, but that Hesiod or one of Hesiod's interpolators composed the verses to please the Messenians.
14: Some say (Asclepius) was the son of Arsinoe, others of Coronis.
Whereon the son of Atreus rose in anger, and threatened that which he has since done.
Ofttimes in my father's house have I heard you glory in that you alone of the immortals saved the son of Saturn from ruin, when the others, with Juno, Neptune, and Pallas Minerva would have put him in bonds.
Thetis wept and answered, "My son, woe is me that I should have borne or suckled you.
Thetis was not unmindful of the charge her son had laid upon her, so she rose from under the sea and went through great heaven with early morning to Olympus, where she found the mighty son of Saturn sitting all alone upon its topmost ridges.
If you really are my son Ulysses," replied Laertes, "and have come back again, you must give me such manifest proof of your identity as shall convince me.
Laertes' strength failed him when he heard the convincing proofs which his son had given him.
When he came back his son was surprised to see him looking so like an immortal, and said to him, "My dear father, some one of the gods has been making you much taller and better-looking.
He was overwhelmed with grief for the death of his son Antinous, who had been the first man killed by Ulysses, so he said, weeping bitterly, "My friends, this man has done the Achaeans great wrong.