Somatotropin receptor | definition of Somatotropin receptor by Medical dictionary
GHR (redirected from Somatotropin receptor)
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GHR A gene on chromosome 5p13-p12 that encodes growth hormone receptor, a type-I cytokine receptor which, once GH is bound, dimerizes and activates the JAK2/STAT5 transduction pathway, leading to growth.
Defects in GHR cause Laron type dwarfism.
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References in periodicals archive
There are reports that the enzymatic removal of N-linked sugar from native bPL increased the binding affinity of somatotropin receptor
for BPL by about 1.2-2.3 fold.
Rapid communication: nucleotide sequence of the promoter and first exon of the somatotropin receptor
gene in cattle.
Greater concentrations of ST apparently caused increased synthesis and release of IGF-I from liver even though the specific somatotropin receptor
involved in this action (GHR-1A) may be less during the transition period (Kobayashi et al., 1999).