Human growth hormone is produced and secreted by somatotrophs
, anterior pituitary cells that secrete almost 1-2 milligrams of hormones every day.
It is auto-regulated during expression and mediates gene expression especially in somatotrophs
, lactotrophs, and thyrotrophs , which play pivotal roles in the growth of the pituitary and hormone secretion in animals .
Growth hormone (GH) is released from pituitary somatotrophs
into the circulation and is essential for postnatal growth and development.
Inactivating mutations in PROP1 perturb ontogenesis of pituitary gonadotrophs, somatotrophs
, lactotrophs, and thyrotrophs.
 localized AdipoRs' expression in the human gonadotrophs, somatotrophs
, and thyrotrophs, but not in corticotrophs or lactotrophs.
Trifunovic et al., "Cortical ablation induces time-dependent changes in rat pituitary somatotrophs
and upregulates growth hormone receptor expression in the injured cortex," Journal of Neuroscience Research, vol.
Clarke, "Signal transduction systems employed by synthetic GH-releasing peptides in somatotrophs
," The Journal of Endocrinology, vol.
Pavan et al., "Biological activity of somatostatin receptors in GC rat tumour somatotrophs
: Evidence with sst1-sst5 receptor-selective nonpeptidyl agonists," Neuropharmacology, vol.
Pit-1 gene expression is essential for the growth of some regulatory processes in the body of animals such as the ability of normal survival, differentiation and development of the three cell types of adenohypophysis, namely somatotrophs
, lactotrophs and thyrotrophs [2,3].
Adenohypophyseal secretory cells include somatotrophs
(nearly 50%), which produce somatotropin (growth hormone, GH); corticotrophs (15-20%), which release adrenocorticotropic hormone; gonadotrophs (10-15%), which synthesize luteinizing hormone and follicle stimulating hormone; thyrotrophs (3-5%), which release thyroid stimulating hormone; and lactotrophs (10-25%), which release prolactin (PRL) (5).
GH deficiency is very common in SS because somatotrophs
are located in the lower and lateral regions of the pituitary gland and are most likely to be damaged by ischemic necrosis of the pituitary.
Wallis, "A procedure for the purification of somatotrophs
isolated from rat anterior pituitary glands using Percoll density gradients," The Journal of Endocrinology, vol.