somatotrope

(redirected from Somatotrophs)

somatotroph

 [so-mat´o-trof″]
a type of acidophil of the adenohypophysis that secretes growth hormone.

somatotrope

/so·mato·trope/ (so-mat´o-trōp) somatotroph.

so·ma·to·troph

, somatotrope (sō-mat'ō-trōf, -trōp)
A cell of the adenohypophysis that produces somatotropin.

somatotrope

somatotroph.
References in periodicals archive ?
Pit-1 gene expression is essential for the growth of some regulatory processes in the body of animals such as the ability of normal survival, differentiation and development of the three cell types of adenohypophysis, namely somatotrophs, lactotrophs and thyrotrophs [2,3].
2001) reported observed a negative effect of leptin on GH-releasing hormone (GHRH)-stimulated GH secretion with reduced GHRH receptor synthesis in somatotrophs from ovine primary cell cultures.
GH deficiency is very common in SS because somatotrophs are located in the lower and lateral regions of the pituitary gland and are most likely to be damaged by ischemic necrosis of the pituitary.
Cytochemical identification of human and murine pituitary corticotrophs and somatotrophs as APUD cells.
Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion.
During aging there are several changes which contribute to the decline in GH/IGF-I including changes in signal to the somatotrophs from growth hormone releasing hormone, somatostatin and other factors such as body composition, exercise, diet and sleep.
In vitro studies have shown that glucocorticoids increase growth hormone gene expression and enhance growth hormone release from cultured rat pituitary somatotrophs (Evans et al.
GH is secreted by the somatotrophs of the anterior pituitary gland and is regulated by stimulatory and inhibitory hypothalamic hormones; neurotransmitters and neuropeptides related to factors affecting GH secretion (such as sleep, stress, exercise, and nutrition); and feedback by circulating levels of GH and IGF-I.
Mechanisms governing the release of growth hormone from acutely dispersed purified somatotrophs.
Melamed et al [106] suggest that estradiol and IGF-I, both generated from cells other than the somatotrophs, may exert antiapoptotic effects and thus possibly control the size of this somatotroph cells.
However, it is unclear from this earlier report whether the pituitary damage is restricted to somatotrophs and results from the tumor burden or from the chronic toxicity of DEN.

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