Medical researchers from Europe, Australia, Japan, the US, and South America address immune-neuro-endocrine reflexes, circuits, and networks; inflammation and thymus aging; intrahypophyseal immune-endocrine interactions; pituitary autoimmunity; the role of prolactin as an immunomodulator in health and disease; anti-PIT-1 antibody syndrome; leptin, neuroinflammation, and obesity; thyroid autoimmunity and cancer; the role of cortistatin in the stressed immune system; steroids and autoimmunity; endocrine autoimmunity in Down syndrome; the somatotrope
growth hormone-releasing hormone/growth hormone/insulin-like growth factor-1 axis in immunoregulation and immunosenescence; and the endocrine immunology of Chagas disease.
Direct modification of somatotrope
function by long-term leptin treatment of primary cultured ovine pituitary cells.
Oudet C, Effets de L'hormone somatotrope
sur la croissance du cartilage condylien et de la synchondrose spheno-occipitale de jeunes rats en culture organotypique.
27) This reflects the autonegative feedback on the somatotrope
from the arginine ingestion.
2004) stated that Pit-1 is an essential for development of somatotrope
, lactotrope, and thyrotrope cells in the anterior pituitary and it transactives expression of the genes encoding GH, PRL, and TSH-b.
GH is synthesized in somatotrope
cells, which are present in the anterior pituitary gland.
In women, the hPL (human Placental Lactogen) acts in a coordinated manner with the somatotrope
hormone, stimulating the production of maternal IGF-1 factor and modulates the intermediate metabolism, which favors the increase of glucose available for its transfer to the fetus (Munoz & Lopez-Oliva, 2004).
cells of the pituitary gland secrete growth hormone whose secretion continues throughout life, although varies based on growth period of humans.
The growth rate is dependent upon the amount of GH secreted by the pituitary somatotropes
with the higher concentrations of GH inducing higher rate of growth in humans (Rogol, 2010).
However, not all kisspeptin positive cells within the pituitary were also LH[beta] positive; therefore, the observed reduction in KiSS-1 mRNA expression may also affect other pituitary cell types, including somatotropes
, lactotropes, and gonadotropes that specifically synthesize FSH.
Intracellular signaling mechanisms mediating ghrelin-stimulated growth hormone release in somatotropes
Board 11 SPERM PROTEIN SP22 IN SOMATOTROPES AND THYROTROPES