somatomedin

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Related to Somatomedins: Somatomedin C, Enamel lamellae

somatomedin

 [so″mah-to-me´din]
any of a group of peptides found in the liver and in other tissues which mediate the effect of growth hormone (somatotropin) on cartilage; they are responsible for uptake of sulfate and increased synthesis of collagen and other proteins by cartilage. Somatomedins also have insulinlike biologic actions and increase RNA synthesis and promote DNA synthesis.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

so·ma·to·me·din

(sō'mă-tō-mē'din),
One of several peptides; somatomedin peptide (MW about 4,000), also called insulinlike growth factor II, is synthesized in the liver and probably in the kidney; it is capable of stimulating certain anabolic processes in bone and cartilage, such as synthesis of DNA, RNA, and protein (including chondromucoprotein), and the sulfation of mucopolysaccharides; secretion and biologic activity of somatomedin is known to depend on somatotropin.
See also: insulinlike growth factor.
[somato, tropin + mediator + -in]
Farlex Partner Medical Dictionary © Farlex 2012

somatomedin

(sō-măt′ə-mēd′n, sō′mə-tə-)
n.
See insulin-like growth factor.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

somatomedin

Any of a group of hormones that mediate the effects of growth hormone (formally, somatopropin):
(1) Insulin-like growth factor-I (somatomedin C);
(2) Insulin-like growth factor-II (somatomedin A);
(3) Vitronectin (somatomedin B).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

so·ma·to·me·din

(sō'mă-tō-mē'din)
A peptide synthesized in the liver, and probably also in the kidney, capable of stimulating certain anabolic processes in bone and cartilage, such as synthesis of DNA, RNA, and protein, and the sulfation of mucopolysaccharides; secretion or biologic activity of somatomedin is known to depend on somatotropin.
[somato, tropin + mediator + -in]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

so·ma·to·me·din

(sō'mă-tō-mē'din)
One of several peptides; also called insulinlike growth factor II, is synthesized in the liver and probably kidney.
[somato, tropin + mediator + -in]
Medical Dictionary for the Dental Professions © Farlex 2012
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References in periodicals archive ?
Serum somatomedin C/IGF-I and IGFBP-3 were determined in duplicate by using a DSL ACTIVE IGF-I and IGFBP-3 immunoradiometric assay (IRMA) kit (Diagnostic System Laboratories, Webster, Texas).
Therefore, our results might most likely reflect the training-induced effect of somatomedin and hormones on cardiac cells.
Serum IGF-I and hormonal responses to incremental exercise in athletes with and without left ventricular hypertrophy
These proteins were initially called somatomedins because of their growth-promoting properties in numerous tissues and the inability to suppress their bioactivity with anti-insulin antibodies (2, 4).
Cultured fibroblast monolayers secrete a protein that alters the cellular binding of somatomedin C/IGF I.
Serum insulin-like growth factors and insulin-like growth factor-binding proteins: clinical implications
The liver has received special attention for the past several decades as a major source of circulating IGF since Salmon and Daughaday (1957) published the somatomedin hypothesis which states that the growth-stimulating action of GH on skeletal tissue is elicited indirectly by "sulfation factor" now known as IGF secreted upon stimulus of GH mostly likely from the liver.
Expression and secretion of the insulin-like growth factor system components by pig liver cells *

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