somatomedin

somatomedin

 [so″mah-to-me´din]

any of a group of peptides found in the liver and in other tissues which mediate the effect of growth hormone (somatotropin) on cartilage; they are responsible for uptake of sulfate and increased synthesis of collagen and other proteins by cartilage. Somatomedins also have insulinlike biologic actions and increase RNA synthesis and promote DNA synthesis.

so·ma·to·me·din

(sō'mă-tō-mē'din),

One of several peptides; somatomedin peptide (MW about 4,000), also called insulinlike growth factor II, is synthesized in the liver and probably in the kidney; it is capable of stimulating certain anabolic processes in bone and cartilage, such as synthesis of DNA, RNA, and protein (including chondromucoprotein), and the sulfation of mucopolysaccharides; secretion and biologic activity of somatomedin is known to depend on somatotropin.
See also: insulinlike growth factor.

[somato, tropin + mediator + -in]

somatomedin

/so·ma·to·me·din/ (so″mah-to-me´din) any of a group of peptides found in plasma, complexed with binding proteins; they stimulate cellular growth and replication as second messengers in the somatotropic actions of growth hormone and also have insulin-like activities. Two such peptides have been isolated, insulin-like growth factors I and II.

somatomedin

(sō-măt′ə-mēd′n, sō′mə-tə-)

n.

See insulin-like growth factor.

somatomedin

See growth hormone.

somatomedin

Any of a group of hormones that mediate the effects of growth hormone (formally, somatopropin):
(1) Insulin-like growth factor-I (somatomedin C);
(2) Insulin-like growth factor-II (somatomedin A);
(3) Vitronectin (somatomedin B).

so·ma·to·me·din

(sō'mă-tō-mē'din)

A peptide synthesized in the liver, and probably also in the kidney, capable of stimulating certain anabolic processes in bone and cartilage, such as synthesis of DNA, RNA, and protein, and the sulfation of mucopolysaccharides; secretion or biologic activity of somatomedin is known to depend on somatotropin.

[somato, tropin + mediator + -in]

so·ma·to·me·din

(sō'mă-tō-mē'din)

One of several peptides; also called insulinlike growth factor II, is synthesized in the liver and probably kidney.

[somato, tropin + mediator + -in]

somatomedin

any of a group of peptides found in the liver and in plasma which mediate the effect of growth hormone (somatotropin) on cartilage; they are responsible for uptake of sulfate and increased synthesis of collagen and other proteins by cartilage.

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somatomedin C

participates in the limitation of secretion of growth hormone by the pituitary; produced in various tissues, especially liver; called also IGF-1 or insulin-like growth factor.