EPHX2

(redirected from Soluble epoxide hydrolase)

EPHX2

A gene on chromosome 8p21 that encodes epoxide hydrolase-2. Epoxide hydrolases are critical biotransformation enzymes that activate and detoxify epoxides by breaking down aromatic compounds to dihydrodiols, which can be conjugated and excreted from the body.
 
Molecular pathology
EPHX2 mutations are associated with familial hypercholesterolaemia.
References in periodicals archive ?
'Inhibitors of soluble epoxide hydrolase to face Niemann-Pick's C disease', by Merce Pallas and Christian Grinan Ferre, from the Department of Pharmacology, Toxicology and Therapeutical Chemistry of the Faculty of Pharmacy and Food Sciences.
However, EETs are degraded to corresponding diols by a soluble epoxide hydrolase (sEH) that is encoded by the EPHX2 gene on chromosome 8p21-p12 [9].
However, when the 13S,14S-epoxy-maresin intermediate is followed by conversion via soluble epoxide hydrolase (sEH), it is then converted to additional bioactive products by human macrophages.
Shen, "Soluble epoxide hydrolase inhibitors: a patent review," Expert Opinion on Therapeutic Patents, vol.
The scope of this part is to discuss [A.sub.2A]AR and [A.sub.1]AR in relation to CYPs, high salt, low salt, and soluble epoxide hydrolase (sEH) in vascular tone regulation.
Global Markets Direct's, 'Soluble Epoxide Hydrolase (Epoxide Hydratase or Aryl Epoxide Hydrase or EC 3.3.2.10) - Pipeline Review, H1 2016', provides in depth analysis on Soluble Epoxide Hydrolase (Epoxide Hydratase or Aryl Epoxide Hydrase or EC 3.3.2.10) targeted pipeline therapeutics.
Distribution of soluble epoxide hydrolase and of cytochrome P450 2C8, 2C9, and 2J2 in human tissues.
Background: Soluble epoxide hydrolase (sEH) has been demonstrated to be a key enzyme involved in the pathologic development of several cardiovascular diseases and inflammation, and inhibition of sEH is therefore very helpful or crucial for the treatment of ischemia-reperfusion injury, cardiac hypertrophy, hypertension and inflammation.
In this study, nitro fatty acids were found to inhibit (block the action of) an enzyme called soluble epoxide hydrolase, and this in turn lowered blood pressure.
Thus, the study concludes that the protective effect of the Mediterranean diet, combining unsaturated fats and vegetables abundant in nitrite and nitrate, comes at least in part from the nitro fatty acids generated which inhibit soluble Epoxide Hydrolase to lower blood pressure.
Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage.