EPHX2

(redirected from Soluble epoxide hydrolase)

EPHX2

A gene on chromosome 8p21 that encodes epoxide hydrolase-2. Epoxide hydrolases are critical biotransformation enzymes that activate and detoxify epoxides by breaking down aromatic compounds to dihydrodiols, which can be conjugated and excreted from the body.
 
Molecular pathology
EPHX2 mutations are associated with familial hypercholesterolaemia.
References in periodicals archive ?
10) - Pipeline Review, H1 2016', provides in depth analysis on Soluble Epoxide Hydrolase (Epoxide Hydratase or Aryl Epoxide Hydrase or EC 3.
The report provides comprehensive information on the Soluble Epoxide Hydrolase (Epoxide Hydratase or Aryl Epoxide Hydrase or EC 3.
Distribution of soluble epoxide hydrolase and of cytochrome P450 2C8, 2C9, and 2J2 in human tissues.
Background: Soluble epoxide hydrolase (sEH) has been demonstrated to be a key enzyme involved in the pathologic development of several cardiovascular diseases and inflammation, and inhibition of sEH is therefore very helpful or crucial for the treatment of ischemia-reperfusion injury, cardiac hypertrophy, hypertension and inflammation.
In this study, nitro fatty acids were found to inhibit (block the action of) an enzyme called soluble epoxide hydrolase, and this in turn lowered blood pressure.
The study, supported by the British Heart Foundation, used mice to investigate the process by which these nitro fatty acids lower blood pressure, looking at whether they inhibited an enzyme known as soluble Epoxide Hydrolase which regulates blood pressure.
Oxylipins that are metabolized by the CYP enzymes are called epoxides, which can be further metabolized by the soluble epoxide hydrolase enzyme into diols.
Recombinant human soluble epoxide hydrolase (sEH) was produced in a baculovirus expression system (Beetham et al.
Earlier research had suggested that a troublesome enzyme, called soluble epoxide hydrolase, degrades natural inflammation inhibitors known as epoxyeicosatrienoic acids (EETs).
Substituted ureas and carbamates are mechanistic inhibitors of the soluble epoxide hydrolase (sEH).
The new study has revealed that analgesia mediated by inhibitors of the enzyme, soluble epoxide hydrolase (sEH), is dependent on a pain-mediating second messenger known as cyclic adenosinemonophosphate or cAMP.