They said the manufacturer of another anti- cutaneous leishmaniasis product, Sodium Stibogluconate
(SSG), should be registered by the Drap for import.
The pentavalent antimonial meglumine antimonate (GlucantimeA(r), Aventis, France, 85 mg Sb5+/mL) for intramuscular and intralesional administration and sodium stibogluconate
(PentostamA(r), 100 mg Sb5+/mL) for intravenous and intramuscular administration have been used for decades for the treatment of CL, and are the gold standard for other new investigational drugs.10
Gurei et al18 in a clinical trial compared the efficacy of intra-lesional sodium stibogluconate
(pentostam) with cryotherapy in the treatment of CL.
Meglumine antimoniate and sodium stibogluconate
are the 2 most commonly used antimonials.
Other studies evaluated the leishmanicidal activity of lapachol and compared its efficacy with a reference drug, sodium stibogluconate
Administration of Pentavalent antimonial drugs such as Sodium stibogluconate
through IV and IM routes is the main method of the treatments despite the clinical representation of the disease [5, 33-35].
Pentavalent antimonials sodium stibogluconate
and meglumineantimoniate are being use as antileishmanial therapy, despite the fact that they are toxic for kidney and heart.
Magnitude of unresponsiveness to sodium stibogluconate
in the treatment of visceral leishmaniasis in Bihar.
Local infiltration with antimonials (sodium stibogluconate
[SSG]100 mg/mL 0.3-3 mL/lesion or meglumine antimonate 0.2-0.8 mL/lesion) was studied in Saudi Arabia in regions where L.
He was admitted to Sir Salimullah Medical College Hospital (SSMCH) and treated with sodium stibogluconate
was used for treatment and patient was discharged on Day 21.
We treated kalaazar case-patients with sodium stibogluconate