As in adults, pediatric FLs contain both small cleaved cells (centrocytes) and large cells (centroblasts) in varying proportions (Figure 3).
Expression of p53 protein is significantly increased in follicular large cell lymphoma (grade 3) compared with follicular small cleaved cell lymphoma (grade 1) in adults.
Twenty-two cases and the following subtypes were retrieved for immunoperoxidase staining of paraffin sections with CD30: follicular, predominantly small cleaved cells (3 cases); follicular, [+ or -] diffuse, mixed, small cleaved, and large cells (10 cases); follicular, [+ or -] diffuse, large cell (8 cases); and diffuse, large cell (1 case).
large cells were seen within the nodules admixed with the small cleaved cells, some of which were centroblastic and with complex nuclear outlines.
The follicles were composed of predominantly small cleaved cells
Most cases of follicular lymphomas that arise in adults are predominantly composed of small cleaved cells.
In this study, the histologic subtype was predominantly small cleaved cell in 30%, mixed small cleaved and large cell in 25%, and predominantly large cell in 45% of cases.
The follicles were composed of a monotonous population of small cleaved cells similar to the follicular lymphoma diagnosed 13 years previously.
We report the unusual case of a 73-year-old man with follicular small cleaved cell lymphoma involving a right groin lymph node 13 years before present admission who had a composite lymphoma, with a combination of nodular sclerosing Hodgkin disease (HD) and follicular small cleaved cell lymphoma.
The patient is a 73-year-old man with a history of NHL, follicular small cleaved cell type, treated with radiation therapy 13 years before the present admission.
The combination of 2 different types of NHL composed of small cleaved cell lymphoma and diffuse large cell lymphoma is the most common variant, accounting for up to 58% of cases.
In composite lymphomas of HD and NHL, the least described variant of NHL is follicular small cleaved cell lymphoma.