As in adults, pediatric FLs contain both small cleaved cells (centrocytes) and large cells (centroblasts) in varying proportions (Figure 3).
Expression of p53 protein is significantly increased in follicular large cell lymphoma (grade 3) compared with follicular small cleaved cell lymphoma (grade 1) in adults.
The follicles were composed of predominantly small cleaved cells
. By immunohistochemical stain, the cells were immunoreactive for CD20, BCL-2, and both CD5 and CD10 (Figure 2).
Most cases of follicular lymphomas that arise in adults are predominantly composed of small cleaved cells. More than 85% of cases contain a characteristic translocation, t(14;18)(q32;q21). This translocation results in the overexpression of a structurally normal BCL-2 protein that inhibits apoptosis.
In this study, the histologic subtype was predominantly small cleaved cell in 30%, mixed small cleaved and large cell in 25%, and predominantly large cell in 45% of cases.
The follicles were composed of a monotonous population of small cleaved cells similar to the follicular lymphoma diagnosed 13 years previously.
We report the unusual case of a 73-year-old man with follicular small cleaved cell lymphoma involving a right groin lymph node 13 years before present admission who had a composite lymphoma, with a combination of nodular sclerosing Hodgkin disease (HD) and follicular small cleaved cell lymphoma.
The patient is a 73-year-old man with a history of NHL, follicular small cleaved cell type, treated with radiation therapy 13 years before the present admission.
The combination of 2 different types of NHL composed of small cleaved cell lymphoma and diffuse large cell lymphoma is the most common variant, accounting for up to 58% of cases. Composite lymphomas, composed of HD and one of the components of NHL, are very rare.
In composite lymphomas of HD and NHL, the least described variant of NHL is follicular small cleaved cell lymphoma.
Subsequently, in 1992, Miettinen described [CD30.sup.+] cells in 51% of nodular small cleaved cell