ivermectin

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Related to Sklice: Ivermectin, Natroba, Ulesfia

i·ver·mec·tin

(ī'vĕr-mek'tin),
A semisynthetic macrolide antibiotic of the avermectin family of compounds, effective in the treatment of filariasis and many other parasites. The drug destroys Onchocerca microfilaria and Filaria bancrofti. Derived from the soil bacterium, Streptomyces avermitilis. Approved by the FDA for the treatment of scabies by topical administration. Widely used in veterinary medicine in a number of species for control of ectoparasites and endoparasites. Unusual sensitivity (increased toxicity, and sometimes death) in collie-type breeds is well documented.

ivermectin

(ī′vər-mĕk′tĕn)
n.
An anthelmintic and acaricide used to treat parasitic infections in livestock, to prevent heartworm infection in dogs, and to treat onchocerciasis, intestinal strongyloidiasis, and head lice in humans.

ivermectin

A drug used to kill MICROFILARIA in the treatment of ONCHOCERCIASIS and other microfilarial diseases. Ivermectin has also been used to treat severe SCABIES in elderly institutionalized people, but an unusually high death-rate in this group cast doubt on the safety of the application. The drug is on the WHO official list.

ivermectin

parasiticide; single-dose treatment for scabies

onchocerciasis 

A disease caused by infestation with the filarial worm (Onchocerca volvulus) spread by blackflies. It is common in tropical Africa and Central America, especially in areas near rivers. Large numbers of microfilariae are present on the skin and often enter the eye. The patient initially complains of itching, but blindness occurs as a result of chorioretinitis and optic neuritis. The disease is treated successfully with ivermectin. Syn. onchocercosis; river blindness.

ivermectin

an avermectin with broad activity against many helminths and arthropods. A broad-spectrum anthelmintic, acaricide and insecticide, used orally, subcutaneously and as a pour-on.
References in periodicals archive ?
The company's Sklice Lotion is used for the topical treatment of head lice infestations in patients six months of age and older.
Sklice Lotion (ivermectin) contains a broad-spectrum antiparasitic agent, ivermectin, which was developed from a soil bacterium that produces a family of compounds (avermectins).
In phase 3 trials, Sklice Lotion (ivermectin) was proven to resolve most head lice infestations with one well-tolerated, ten minute application in two weeks duration, said the company.
Sklice Lotion should be used in the context of an overall lice management program, which includes washing (in hot water) or dry-cleaning all recently worn clothing, hats, used bedding and towels, as well as washing personal care items such as combs, brushes and hair clips in hot water.
Sklice Lotion is being commercialized by Sanofi Pasteur U.
The company said that its Sklice Lotion, which is effective, well-tolerated and formulated with ivermectin, treats lice in most patients with a single ten minute application of the lotion, without nit combing.
In conjunction with the FDA approval, Sklice will be commercialised by Sanofi Pasteur US, which is engaged in bringing solutions to the pediatric healthcare community.