Pemphigus is a disease of high morbidity and mortality due to extensive erosions leading to acute skin failure
. However, mortality rates have drastically reduced from 75% in pre-corticosteroid era to 25 - 45% after the advent of corticosteroids.
The concept of "skin failure" does not have the long history and public understanding associated with other forms of organ failure.
In 2006, Langemo and Brow proposed a working definition of skin failure, which included skin failure being the result of hypoperfusion, the creation of severe inflammatory reaction, or failure of multiple organ systems.
Dermatological emergencies comprise diseases with severe alterations in structure and function of the skin, with some of them leading to acute skin failure
that demands early diagnosis, hospitalization, careful monitoring and multidisciplinary intensive care to minimize the associated morbidity and mortality.
The first load drop depicted from the curve indicated the top skin failure
at the impacted region.
Now, focusing on that same image, re-label it "skin failure
." Suddenly, the identical wound no longer looks or "feels" the same.
Topics covered include cell injury and death; new antimicrobials; immunomodulators and biologics; acute skin failure
; neonatal emergencies; necrotizing soft tissue and bacterial skin infections; viral, fungal, and parasitic diseases; stings, bites, and marine envenomations; drug, allergic, and immunological reactions; complications of dermatologic therapies; purpura and vasculitis; connective tissue disorders and their complications; skin signs of systemic infections and neoplastic and paraneoplastic diseases; sexually transmitted diseases; torture and self-inflicted dermatoses; environmental skin disorders; signs of poisoning; disaster planning; and catastrophes in cosmetic procedures.
The acutely ill older adult is at even greater risk of skin failure
as the body fights to provide more circulation to the diseased system.
"You have to recognize that this condition represents an acute skin failure
There is no such thing as "skin failure
," in medical terms.