SCN4A

(redirected from SkM1)

SCN4A

A gene on chromosome 17q23.3 that encodes an alpha subunit of a transmembrane glycoprotein complex, which forms a voltage-gated sodium channel. The SCN4A protein product is expressed in skeletal muscle.

Molecular pathology
SCN4A mutations are linked to various myotonic and periodic paralysis disorders.
References in periodicals archive ?
Jacquel et al., "Phenotypic and genotypic characterization of azacitidine-sensitive and resistant SKM1 myeloid cell lines, " Oncotarget, vol.
Puissant et al., "Azacitidine-resistant SKM1 myeloid cells are defective for AZA-induced mitochondrial apoptosis and autophagy, " Cell Cycle, vol.
(a) TTX [alpha] subunit Older names sensitivity [Na.sub.v] 1.1 Rat I, HBSCI, GPBI, TTX-S SCN1A [Na.sub.v] 1.2 Rat II, HBSCII, HBA TTX-S [Na.sub.v] 1.3 Rat III TTX-S [Na.sub.v] 1.4 SkM1, [micro]1 TTX-S [Na.sub.v] 1.5 SkM2, H1 TTX-R [Na.sub.v] 1.6 NaCh6, PN4, Scn8a, TTX-S Cerlll [Na.sub.v] 1.7 NaS, hNE-NA, PN1 TTX-S [Na.sub.v] 1.8 SNS, PN3, NaNG TTX-R [Na.sub.v] 1.9 NaN, SNS2, PN5, TTX-R NaT, SCN12A [Na.sub.x] [Na.sub.v] 2.1, [Na.sub.v] 2.3 Na-G, ?