Six-Cities Study

Six-Cities Study

A study linking exposure to particulate—less than 10 µm in diameter—pollutants and particles from fossil fuel combustion (e.g., carbon, hydrocarbons, dust, acid aerosols, sulphates) to increased mortality due to COPD, asthma and cardiovascular disease, resulting in an excess of 60,000 deaths/year in the USA.
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One of them was a seminal study known as the Harvard Six-Cities Study, which followed a cohort of over 8,000 participants for 17 years to assess the effects of air pollution.
Six-cities and ACS studies I The first epidemiological study at issue is the "six-cities study" of 8,111 adults undertaken by researchers at the Harvard School of Public Health.
As pointed out by Brunekreef, the Harvard six-cities study published in the 1993 New England Journal of Medicine established measurable health effects of fine particle exposure.
For example, the Harvard Six-Cities Study (Dockery et al.