sirtuin


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sirtuin

(sûr′to͞o-ĭn, -tyo͞o-)
n.
Any of a family of enzymes that occur in all living organisms and are thought to regulate cellular aging, apoptosis, and resistance to stress in more complex eukaryotic organisms.
Any of a class of proteins that possess either histone deacetylase—more commonly—or mono-ribosyltransferase activity, named after Sir2, the cell-regulating yeast gene silent mating-type information regulation 2. Sirtuins regulate critical biological pathways in eubacteria, archaea and eukaryotes.
Sirtuins influence ageing, transcription, apoptosis, stress resistance, and affect energy efficiency and alertness during hypoglycaemia
Most sirtuins are protein deacetylases in which sirtuin-mediated deacetylation couples lysine deacetylation to NAD hydrolysis—instead of simple hydrolysis of acetyl-lysine residues—yielding O-acetyl-ADP-ribose, the deacetylated substrate and nicotinamide. The dependence of sirtuins on NAD links their enzymatic activity directly to the energy status of the cell via the cellular NAD:NADH ratio, the absolute levels of NAD, NADH or nicotinamide or a combination of these variables.

sirtuin

(sĭr′too-ĭn)
Any of a class of proteins that are coded by the SIR family of genes. These proteins contribute to chromosome repair and may have a role in extending the life span of cells.
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Sirtuin 1, or SIRT1, is known to play an important role in maintaining metabolic balance in multiple tissues, and studies in various organisms have shown that activating the protein can lead to many health benefits.
Protein Sirtuin have long been connected to lifespan extension and calorie restriction.
Verdin, "Conserved metabolic regulatory functions of sirtuins," Cell Metabolism, vol.
That the vascular metformin requires sirtuin 1 is particularly noteworthy, as this protein has been linked to a protective role against metabolic disease associated with premature ageing," he stated.
Scientists believe it stimulates a sirtuin known as SIRT1 that breaks up certain proteins, helping them change cell behaviour in ways that are beneficial to health.
Further studies on Sirtuin will provide better therapies to improve age- associated changes, such as diabetes, cancer and cardiovascular disease, and possibly it can extend healthy human lifespan.
Accordingly, the present study was aimed to examine Sirtuin expression profiles in peripheral blood mononuclear cells (PBMC) following systemic LPS administration in healthy humans to clarify the involvement and potential roles of SIRT in the systemic inflammatory response of humans.
Sirtris is the most high-profile shop working on sirtuins and resveratrol-like pharmacology, which subject has received a massive amount of press (some accurate, some scrambled).
Estee Lander Co.'s Time Zone line-and wrinkle-reducing moisturizers likewise boast Sirtuin EX1 Technology and claim to stimulate proteins for a more youthful look.
Resveratrol, he explains, appears to activate what are known as the sirtuin genes--sometimes referred to as scarcity or longevity genes.