Paget, Sir James

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Paget, Sir James

Brit. surgeon, 1814–1899.

extramammary Paget disease

A plaque with a definite margin found in the anogenital area and in the axilla. It is a rare malignant disease and is treated by surgical excision.

Paget disease

A chronic form of osteitis of unknown cause affecting older people, causing thickening and hypertrophy of the long bones and deformity of the flat bones. Synonym: osteitis deformans.


Symptoms are insidious in onset and include pain in the lower limbs (esp. the tibia), frequent fractures, waddling gait, and shortened stature. The skull often becomes enlarged, and hearing may be affected.


Common treatments include bisphosphonate drugs (e.g., alendronate and etidronate). Acetaminophen, aspirin, and other nonsteroidal anti-inflammatory drugs are often used to control pain.

Paget disease of the breast

Carcinoma of the mammary ducts. The tumor extends to the nipple and aureola, often presenting as a red, crusty rash, scaly skin, or an oozing, eczematous discharge. The patient may complain of itching or burning. Biopsy confirms the diagnosis.
Medical Dictionary, © 2009 Farlex and Partners


Sir James, English surgeon, 1814-1899.
extramammary Paget disease - Synonym(s): Paget disease
Paget abscess syndrome - an abscess recurrence at the same site after apparent cure.
Paget associated osteogenic sarcoma
Paget cells - relatively large neoplastic epithelial cells.
Paget disease - an intraepidermal form of mucinous adenocarcinoma, most commonly in the anogenital region. Synonym(s): extramammary Paget disease
Paget disease of bone - osteitis deformans. Synonym(s): Paget II syndrome
Paget disease of the nipple - ductal carcinoma.
Paget disease of the penis - carcinoma that develops after balanitis.
Paget juvenile syndrome - Synonym(s): familial osteoectasia
Paget quiet necrosis - necrosis in the superficial layers of the shaft of a long bone.
Paget I syndrome - relationship to or possible extension of mammary duct carcinoma.
Paget II syndrome - Synonym(s): Paget disease of bone
Paget test - to determine whether a mass is a solid tumor or a cyst.
Paget-von Schrötter syndrome - stress thrombosis or spontaneous thrombosis of the subclavian or axillary vein. Synonym(s): effort-induced thrombosis
Medical Eponyms © Farlex 2012
References in periodicals archive ?
This man, Sir James Paget, is considered to be one of the founders of modern pathology and one of the surgical "greats" of 19th century England (see Figure 1).
Sir James Paget, reflecting on his experiences at St Bartholomew's Hospital in London during 1835 - 1854, noted: 'Some of the self-select of the pupils, making themselves into a kind of club, had a small room over a baker's shop near the Hospital's gate where we could sit and read the journals'.
That was followed by a report on the death of the famous surgeon and lecturer, Sir James Paget, in London.