The hepatic parenchyma in fish is made up of two cellular plates surrounded by sinusoids
. Between two neighboring sinusoids
, the hepatocytes are arranged as cords, generally two cells thick.
Since the PSD of a sinusoid
is the same as that of its phase-shifted version, it follows that
NO is released from the both the non-adrenergic non-cholinergic (NANC) nerves that supply the penis, and also from the endothelial cells that line the sinusoids
. The endothelial cells are triggered to release NO by acetylcholine from parasympathetic nerve fibres that are active during sexual stimulation.
AQP1 was expressed in hepatic sinusoids
, Kupffer cells (Macrophagocytus stellatus) and hepatocytes (Fig.
Thus, two periods are distinguished: (1) the Gd-BOPTA perfusion period that evidences how the contrast accumulates in the liver compartments, and (2) the Gd-BOPTA rinse period that investigates how the contrast leaves hepatocytes into bile canaliculi and back into sinusoids
. To quantify both contrast agents with the gamma counter, we add [sup.153]Gd[Cl.sub.3] to 0.5 [micro]M Gd-BOPTA or Gd-DTPA solutions (1 MBq/ml).
The immunohistochemical staining of the liver with anti CD68 antibody shows a normal number, distribution and immune density of CD68 positive phagocytic, characteristic Kupffer cells in the wall of the hepatic blood sinusoids
. Whereas sections from rat receiving APAP showing the appearance of scattered aggregations of intensely immuno-stained cells especially around the central vein (center-lobular zone).
Caption: Figure 6: High magnification field shows thick trabecula compressed into compact mass surrounded by sinusoids
Combinedwith the data above, we demonstrated that plumbagin contributes to the reversal of pathological changes seen in leptin-stimulated LSECs such as the capillarization of hepatic sinusoids
via downregulating ET-1, VEGF, LN, and type IV collagen expression.
Toxic injury to hepatic sinusoids
: sinusoidal obstruction syndrome (veno-occlusive disease).
of liver of group I albino rat (control group) showing central vein (a), Hepatic sinusoids
(b), Plates of hepatic cells (c).
In the CRLB, the ESPRIT-based TOA estimation is based on a single-tone sinusoid
The Hepatic Stellate Cells (HSCs) activity reflects the chief event in hepatic fibrogenesis.3 HSCs are a resident of perisinusoidal space (or space of Disse) which is between the endothelial wall of the sinusoid
and the vascular surface of the hepatocytes.4 Due to the cytokines produced by injured hepatocytes HSCs lose their retinols and are converted into myofibroblasts which are contractile and fibrogenic.5 These transformed HSCs express some mesenchymal markers including Alpha Smooth Muscle Actin (a-SMA) which is a reliable and widely used marker of activated HSCs.56