single nucleotide polymorphism

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polymorphism

 [pol″e-mor´fizm]
the ability to exist in several different forms.
balanced polymorphism an equilibrium mixture of homozygotes and heterozygotes maintained by natural selection against both homozygotes.
genetic polymorphism the occurrence together in the same population of two or more genetically determined phenotypes in such proportions that the rarest of them cannot be maintained merely by recurrent mutation.
single nucleotide polymorphism (SNP) a genetic polymorphism between two genomes that is based on deletion, insertion, or exchange of a single nucleotide.

single nucleotide polymorphism (SNP),

the naturally occurring substitution of a single nucleotide at a given location in the genome of an organism, the more interesting of which results in phenotypic variability, including alterations in the organism's physiologic responses to endogenous hormones and neurotransmitters or endogenous substances.

single nucleotide polymorphism (SNP)

a genetic polymorphism between two genomes that is based on deletion, insertion, or exchange of a single nucleotide.

single nucleotide polymorphism (SNP, ‘snip’)

a single BASE PAIR position in genomic DNA where different sequence alternatives exist for normal individuals in the population. Differences between individual genomes are largely due to SNPs. Over 1.4 million SNPs have been identified in the human GENOME. SNPs in coding regions of the genome are designated cSNPs; those in regulatory regions, rSNPs; and those in JUNK DNA regions, anonymous SNPs. SNPs generate variability, particularly where they occur in coding regions, thereby contributing to the biological characteristics of an individual. For example SNPs reflect differences in susceptibility to, and protection from, a range of diseases. An SNP can be detected by OLIGONUCLEOTIDE HYBRIDIZATION, using for example DNA CHIPS.
References in periodicals archive ?
Paulson says, "Because the human genome is full of polymorphisms, including countless single-nucleotide polymorphisms, it is conceivable that some of these might be associated with diseases, or traits, that allow them to be the 'hook' by which selective targeting [of a gene] can occur.
Specifically, this new OS gene test (Patent Pending) is designed to measure single-nucleotide polymorphisms, or SNPSs (pronounced "snips"), which are small variations in DNA.
The symposium occurred only weeks after completion of Phase 1 of the EGP, which called for the resequencing of more than 200 environmentally responsive genes for the purpose of identifying single-nucleotide polymorphisms, or SNPs, that are important in determining disease susceptibility.
Single-nucleotide polymorphisms (SNPs) are the simplest differences to examine on the wide scale, agreed participants at Genetic Variation and Gene-Environment Interaction in Human Health and Disease, a seminar held 16 April 2003 at the NIH campus in Bethesda, Maryland.

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