single nucleotide polymorphisms

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sin·gle nu·cle·o·tide pol·y·mor·phisms

(sing'gĕl nū'klē-ō-tīd pol'ē-mōrph'izmz)
Variation between two DNA sequences consisting in the difference of a single nucleotide, frequently the substitution of thymine for cytosine. Although the possession of a pair of alleles displaying such polymorphism seldom causes demonstrable abnormality or malfunction, it may influence the response to pathogens, toxins, and environmental agents and enhance susceptibility to certain conditions.
References in periodicals archive ?
This study has investigated five single nucleotide polymorphisms in TNF-[alpha] gene's promoter region to evaluate their relationship with recurrent pregnancy loss disorder.
Relationship between rs1800795 single nucleotide polymorphisms and serum interleukin-6 level in different neuroblastoma-risk groups and MYCN gene amplification status groups
Keywords: Arginine vasopressin receptor, AVPR, Hepatorenal syndrome, HRS, Single nucleotide polymorphisms, SNPs, Liver cirrhosis.
Role of single nucleotide polymorphisms in estrogen-metabolizing enzymes and susceptibility to uterine leiomyoma in Han Chinese: a case-control study.
Profiling single nucleotide polymorphisms (SNPs) across intracellular folate metabolic pathway in healthy Indians.
Thirteen single nucleotide polymorphisms (SNPs) that already had confirmed associations with type 1 diabetes or celiac disease were investigated.
That's because scientists are at work cataloging roughly 50,000 single nucleotide polymorphisms, or SNPs--the variations in DNA that make soybean varieties different from each other-occurring in over 19,000 unique lines, or accessions, that make up the extensive USDA soybean germplasm collection.
By measuring over 100,000 single nucleotide polymorphisms (SNPs), the array can detect more detailed copy number changes than conventional CGH, and offers many times more markers than microsatellite analysis for LOH studies.
Genotyping identified all single nucleotide polymorphisms in a region that contained the CREB1 gene.
27 that they have developed a prototype of a fully automated SNPs (single nucleotide polymorphisms) analysis system.
Microarray-based method for genotyping of functional single nucleotide polymorphisms using dual-color fluorescence hybridization.
Project goals include new molecular diagnostic instruments and the development of new techniques for using single nucleotide polymorphisms for DNA profiling in criminal cases.

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