Bulldog Syndrome

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An X-linked dysmorphia complex [MIM 312870] which is characterised by a large, square protruding jaw, a broad nasal bridge, an upturned nose tip, and macroglossia, resulting in a physiognomy fancifully likened to that of a bulldog, and broad short hands and feet, occasionally with polydactyly, and other defects including pectus excavatum, ventricular septal defect (or other congenital heart defects), Meckel diverticulum, intestinal malrotation, and congenital diaphragmatic hernia, and paediatric tumours, e.g., Wilms tumour, neuroblastoma


J.L., U.S. physician.
Simpson syndrome - X-linked dysmorphia syndrome. Synonym(s): bulldog syndrome
References in periodicals archive ?
Cardiac anomalies in the Simpson-Golabi-Behmel syndrome.
Genital anomalies in three male siblings with Simpson-Golabi-Behmel syndrome.
Novel duplication in glypican-4 as an apparent cause of Simpson-Golabi-Behmel syndrome.
Simpson-Golabi-Behmel syndrome is rare with a broad range of associated medical problems.
GPC3 mutations in seven patients with Simpson-Golabi-Behmel syndrome.