Bulldog Syndrome

(redirected from Simpson-Golabi-Behmel syndrome)
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An X-linked dysmorphia complex [MIM 312870] which is characterised by a large, square protruding jaw, a broad nasal bridge, an upturned nose tip, and macroglossia, resulting in a physiognomy fancifully likened to that of a bulldog, and broad short hands and feet, occasionally with polydactyly, and other defects including pectus excavatum, ventricular septal defect (or other congenital heart defects), Meckel diverticulum, intestinal malrotation, and congenital diaphragmatic hernia, and paediatric tumours, e.g., Wilms tumour, neuroblastoma

Simpson,

J.L., U.S. physician.
Simpson syndrome - X-linked dysmorphia syndrome. Synonym(s): bulldog syndrome
References in periodicals archive ?
Clinical and molecular aspects of the Simpson-Golabi-Behmel syndrome. Am J Med Genet 1998; 79(4):279-283.
Cardiac anomalies in the Simpson-Golabi-Behmel syndrome. Am J Med Genet 1999; 83(5):378-381.
Genital anomalies in three male siblings with Simpson-Golabi-Behmel syndrome. Am J Med Genet 2009; 149A(11):2484-2488.
Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: Identification of loss-of-function mutations in the GPC3 gene.
Expanding the clinical picture of Simpson-Golabi-Behmel syndrome. Pediatr Neurol 2006; 34:139-142.
Anesthetic management in a patient with Simpson-Golabi-Behmel Syndrome. Masui 2001; 50:1106-1108.