Simpson-Angus Scale

A 10-item testing instrument used to evaluate drug-related extrapyramidal syndromes.

Items in SAS
Gait, arm dropping, shoulder shaking, elbow rigidity, wrist rigidity, leg pendulousness, head dropping, glabella tap, tremor, salivation.

Range of scores
0–40; increased scores indicate increased severity.

Simpson-Angus Scale

Pharmacology A testing instrument–range of scores, 0–40, ↑ scores indicate ↑ severity, for evaluating drug-related extrapyramidal syndromes. See Extrapyramidal syndrome.

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References in periodicals archive ?

Participants were also assessed utilizing the Barnes Akathisia Ratings Scale (BARS) for akathisia and the Simpson-Angus Scale (SAS) for parkinsonism.

Neurocrine Announces Positive Results from Phase III Kinect 3 Study of NBI-98854 in Tardive Dyskinesia

In addition, 7% experienced treatment-emergent extrapyramidal symptoms as defined by a Simpson-Angus Scale score of 3 or less at baseline rising to greater than 3 on treatment.

Cariprazine performs well for mania in 16-week trial

Extrapyramidal symptoms were evaluated using the Simpson-Angus scale (Simpson and Angus 1979), Barnes Akathisia scale (Barnes 1989), and abnormal involuntary movement scale (AIMS) (National Institute of Mental Health 1976b).

Yokukansan (TJ-54) for treatment of very-late-onset schizophrenia-like psychosis: an open-label study

Tolerability was measured using the Simpson-Angus Scale (SAS) and various laboratory measurements

New Study Shows Equivalent Efficacy and Superior Tolerability of quetiapine Compared to risperidone in the Treatment of Schizophrenia

The safety and efficacy of intramuscular ziprasidone were evaluated by using the following instruments: Behavioral Activity Rating Scale (BARS) (responders were defined a priori as having a [greater than or equal to] 2-point reduction in BARS score); Clinical Global Impressions, severity of illness (CGI-S) and global improvement (CGI-I) scales; Positive and Negative Syndrome Scale (PANSS); Barnes Akathisia Scale (BAS); and Simpson-Angus Scale (SAS) (4).

Ziprasidone mesylate (Geodon for injection): the first injectable atypical antipsychotic medication

Participants were assessed utilizing the Barnes Akathisia Ratings Scale (BARS) for akathisia and the Simpson-Angus Scale (SAS) for parkinsonism.

Neurocrine Announces 12-Week Safety Results From Initial Phase IIB Study Of VMAT2 Inhibitor NBI-98854

Participants will be randomized to 100 mg/day of amisulpride or placebo for 12 weeks, with the primary outcomes being change in the Brief Psychiatric Rating Scale, a quality of life measure, and the Simpson-Angus Scale of Parkinsonian symptoms.

Late-life psychosis mimics schizophrenia

At the same time, they assessed adverse events using the Simpson-Angus Scale, Barnes Akathisia Rating Scale, and the Abnormal Involuntary Movement Scale.

Aripiprazole wins out in comparison with olanzapine

Patients treated with haloperidol also experienced a significant increase in extrapyramidal symptoms (EPS) compared to aripiprazole patients, as measured by mean change from baseline to endpoint in the Simpson-Angus Scale (1.

Results from new clinical studies: Aripiprazole significantly improved symptoms of acute bipolar mania

Safety and tolerability were assessed by the Modified Simpson-Angus Scale (SAS) and the Barnes Akathisia Rating Scale (BARS), where results showed fewer patients on SEROQUEL experienced EPS and akathisia than those on mood stabilizers alone.

AstraZeneca Seeks New Indication for SEROQUEL(R); Application Submitted to the FDA for the Treatment of Bipolar Disorder

No significant changes were observed in Abnormal Involuntary Movement Scale (AIMS), Simpson-Angus Scale (SAS), or Barnes Akathisia Scale (BAS) at baseline and at the end of the study.

SEROQUEL Studied in Adolescent Patients with Psychotic Disorder

Safety and tolerability were also assessed weekly using the Simpson-Angus Scale (SAS), Barnes Akathisia Scale (BAS), Abnormal Involuntary Movement Scale (AIMS), laboratory tests and vital signs.

Study Reports Positive Results for SEROQUEL as an Adjunctive Treatment For Adolescent Mania