silibinin

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silibinin

One of two major constituents of silymarin (silibinins A and B), the main extract of milk thistle (Silybum marianum seeds), which have hepatoprotective effects (e.g., against Amanita phalloides (deathcap mushroom) poisoning) and anti-cancer activity (in animal models) against prostate adenocarcinoma, breast carcinoma cells, cervical carcinoma cells, colon cancer and both small and non-small lung carcinomas. It may also be useful for cirrhosis and type-2 diabetes.
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Silymarin and silybin alter the structure of the hepatocyte cell membrane and other constituents may bind to the hepatocyte receptors to inhibit the binding of toxins.
Parris K, Kathlin H, A review of the bioavailability and clinical efficacy of Milk Thistle Phytosome: A Silybin Phosphatidylcholine complex; Alternative Medicine Review Vol 10, 3, 2005, 193-194
Silymarin but not silybin dose dependently (1-10 mcg/ kg iv) reduced CI/R induced brain infarction by 16-40%.
In addition to reducing insulin resistance, a major factor in progression of non-alcoholic fatty liverdisease to non-alcoholic steatohepatitis, silybin has also been shown to target and reduce central obesity by regulating the expression of key enzymes and genes involved in the breakdown of lipids (lipolysis) and the formation of glucose (gluconeogenesis), leading to enhanced fat breakdown and inhibition of new glucose production.
Tokyo, Japan, Oct 5, 2005 - (JCNN) - Japanese cosmetic manufacturer FANCL announced on September 29 that it has presented research results of silybin, an extract derived from milk thistle seeds, at the International Federation of Societies of Cosmetics Chemists (IFSCC) International Conference 2005 held in Italy, from September 19 to 21.
Curcumin, resveratrol, and silybin are examples of popular polyphenol supplements for which preclinical findings cannot be readily extrapolated to the clinical environment.
11), (12) This new delivery system also resulted in 5-fold greater concentrations of silybin in the bloodstream which is important because milk thistle extracts have potent systemic benefits.
1% silybin (Tedesco 2004) increase in breastmilk From 10 days prior to ex- volume of 64.
Specifically, she reviewed the potency and application of a range of ingredients including green tea, resveratrol, ergothioneine, silybin marianum fruit extract, L-ascorbic acid, grape seed, growth factors and idebenone.
The company's botanical ingredients include Mirtoselect bilberry, Leucoselect grape seed, Greenselect green tea, Opextan olive pulp and Siliphos silybin.