silent mutation

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Related to Silent mutations: Nonsense mutations, Missense mutations

si·lent mu·ta·tion

the form of a genetic trait distinguishable at the genotypic level but not at the level of arbitrary phenotype (for example, clinical, immunologic, or electrophoretic).

silent mutation

A genetic mutation that does not result in a change of phenotype.

silent mutation

A change in DNA that has no effect.

silent mutation

a MUTATION that does not result in any change in the GENE product or PHENOTYPE of an ORGANISM, even though there has been a change in the DNA base sequence.

References in periodicals archive ?

Among these mutations, EX3_62delA showed a silent mutation, EX3_ 63T/A showed a missense mutation leading to the changes Se [right arrow] His, and EX3_83A/T showed a nonsense mutation (Figure 2B).

Association analysis of polymorphisms in six keratin genes with wool traits in sheep

Again, we excluded 14 polymorphisms, 4 silent mutations, and 49 variants detected in introns or untranslated regions.

Genotyping of 25 leukemia-associated genes in a single work flow by next-generation sequencing technology with low amounts of input template DNA

Silent mutation at G779G found that though it was a synonymous mutation the genotypic variations might influence the response to TKI as seen with Q787Q.

Association of EGFR gene polymorphism in head and neck cancer patients with tobacco and alcohol consuming habits

CAP+1 mutation, the only silent mutation in the study was present in 4 Punjabis, 4 Pathans and 1 other carrier (Table-1).

Prevalence of various mutations in beta thalassaemia and its association with haematological parameters

Results were not altered substantially for missense, nonsense, and silent mutations (data not shown).

Associations between polycyclic aromatic hydrocarbon-related exposures and p53 mutations in breast tumors

To investigate whether silent mutations play a role, Gottesman and his colleagues worked with different varieties of the gene called MDR1, which makes P-glycoprotein.

Not so silent: mutation alters protein but not its components

In addition, we observed 3 silent mutations in gyrB and 1 silent mutation in parC.

Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae clone

Most of the mutations represented coding mutations, which were classified as missense (n = 19), deletions (n = 5), insertions (n = 1), and silent mutations (n = 2).

Detection of androgen receptor mutations in circulating tumor cells in castration-resistant prostate cancer

Of the four silent mutations 42 (ag), 138 (c [right arrow] t), 231 (c [right arrow] a) and 237 (g [right arrow] c) detected in this study, 237 (g [right arrow] c) is novel.

Prion protein genotypes in Pakistani goats

(e) Two examples are silent mutations in three mutation samples.

Unventilated indoor coal-fired stoves in Guizhou province, China: cellular and genetic damage in villagers exposed to arsenic in food and air

However, all of the observed nucleotide differences represented silent mutations between Egypt MLB1 and Australia and US isolates; comparison of partial capsid protein sequences indicated no amino acid changes.

Novel astroviruses in children, Egypt

The majority of these unstable Hbs result from electrophoretically silent mutations within the hydrophobic core of the protein (6), and thus examination of the redissolved isopropanol precipitate by mass spectrometry can be very helpful in the search for a suspected unstable Hb (8).