silent mutation

Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia.

Related to silent mutation: genetic code, Nonsense mutation

si·lent mu·ta·tion

the form of a genetic trait distinguishable at the genotypic level but not at the level of arbitrary phenotype (for example, clinical, immunologic, or electrophoretic).

silent mutation

A genetic mutation that does not result in a change of phenotype.

silent mutation

A change in DNA that has no effect.

silent mutation

a MUTATION that does not result in any change in the GENE product or PHENOTYPE of an ORGANISM, even though there has been a change in the DNA base sequence.

References in periodicals archive ?

The mutation 2466 C [right arrow] T was a silent mutation. Mutation 1442 T [right arrow] C leads to the amino acid substitution Val 159 [right arrow] Ala, located in the variable region close to the glycosylation site.

Genetic variability of West Nile virus in US blood donors, 2002-2005

The five W-Beijing isolates with a mutation in mutT4 and a wild-type mutT2 gene did not contain the ogt silent mutation on codon 12 either.

Mutations in putative mutator genes of Mycobacterium tuberculosis strains of the W-Beijing family. (Research)

Additionally, rare inactivating variants (TPMT*3B, *3D, *4, *5, *6, *7, and *8) as well as some intronic and silent mutations have been reported, although mostly in single individuals (16, 24, 27) (Fig.

High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC

Silent mutations are often described in fluoroquinolone sensitive and resistant strains and many combinations of transitions and mutations may exist.

Detection of fluoroquinolone resistance by mutation in gyrA gene of Campylobacter spp. isolates from broiler and laying (Gallus gallus domesticas) hens, from Rio de Janeiro State, Brazil/Deteccao de resistencia as fluoroquinolonas atraves da mutacao no gene gyrA em Campylobacter spp. isolados de frangos de corte e galinhas (Gallus gallus domesticas) poedeiras, no Estado do Rio de Janeiro, Brasil

Mutations in codon 503 520 and 554 were silent mutations as they did not change the encoded amino acid.

Identification of single nucleotide polymorphism in rpoB gene among Mycobacterium tuberculosis isolates from Pakistan

DNA sequencing of direct patient samples (or if not available, isolates) with possible RMP resistance should include genetic loci associated with resistance to RMP (to include rpoB) as well as isoniazid (to include inhA and katG) to assess for multidrug/ resistant tuberculosis; rpoB mutations detected by the Xpert MTB/RIF assay might be silent mutations that do not affect RMP susceptibility.

Availability of an assay for detecting mycobacterium tuberculosis, including rifampin-resistant strains, and considerations for its use--United States, 2013

To compare results generated from gDNA and WGA samples, we analyzed all detected variants, including SNPs, silent mutations, and variants located in introns or untranslated regions.

Genotyping of 25 leukemia-associated genes in a single work flow by next-generation sequencing technology with low amounts of input template DNA

Three silent mutations in other sheep breeds, except for Minxian Black-fur and Kazakh Fat-Rumped breeds, have three genotypes.

Mutations in MC1R gene determine black coat color phenotype in Chinese sheep

This was true even for seemingly insignificant genetic changes known as "silent mutations," which swap out a single DNA letter without changing the ultimate gene product.

New Layer of Genetic Information Helps Determine How Fast Proteins Are Produced

The five silent mutations p.C6C, p.R450R, p.R723R, p.N570N and p.V632V described previously in Moroccan population (9,10) were also detected in our sample.

Identification of four novel LDL receptor gene mutations in the north-west Moroccan population

PAH exposures were also inconsistently related to p53 missense, nonsense, and silent mutations (Table 4).

Associations between polycyclic aromatic hydrocarbon-related exposures and p53 mutations in breast tumors

However, experiments by Michael Gottesman of the National Cancer Institute in Bethesda, Md., and his colleagues led the team to suspect that those silent mutations might lead to significant differences.