signal transduction

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signal transduction

n.
The process by which a signal, such as a hormone or a change in the concentration of an ion, is converted into a biochemical response by means of the activation of a receptor on the surface or interior of a cell.

signal transduction

Biochemical conversion that is part of a process, such as the docking of hormone to receptor, stimulating cellular production of specific enzymes or other proteins.
See also: transduction

signal transduction

The common process by which the binding of a molecule to a receptor on a cell plasma membrane results in the transmission of a signal within the cell (second messenger) to trigger off a biochemical pathway in the cell.

signal transduction

control of cellular activity by way of an extracellular signal being transduced into an intracellular response. This involves a cell surface receptor that responds to an external signalling compound by carrying the signal across the cell membrane to influence intracellular activities, such as expression of the genome. For example, the compound may bind to the receptor, altering its conformation, and result in the activation of an intracellular protein by phosphorylation. This, in turn, can initiate the transduction pathway in the cell. Some signals to which cells respond are ANTIGENS, HORMONES, GROWTH FACTORS, and the availability of nutrients or toxic substances.
References in periodicals archive ?
The Wnt/[beta]-catenin signaling pathway controls numerous processes in embryonic development, such as the formation of the body axis and of organ primordia, and is particularly active in embryonic and adult stem cells.
Lilly scientists have identified that Lilly's Hedgehog inhibitor is a small molecule antagonist of Smoothened (Smo), a key regulator of the Hh signaling pathway, binding to it and inhibiting Hh signaling in a human medulloblastoma tumour cell.
sFRP1 is part of a signaling pathway involving a series of other genes known as the WNT-signaling pathway.
To see how hedgehog and other signaling pathways might affect fat development, endocrinologist Jonathan Graff of the University of Texas Southwestern Medical Center in Dallas and his colleagues studied the effects of activating and blocking the hedgehog and other pathways.
Upon execution of the final agreement, the principal goals of the research program will be to advance the functional understanding of an undisclosed UOM protein in neurodegenerative diseases by researching its signaling pathways.
Professor Christian Doerig and his colleagues tested red blood cells infected with Plasmodium falciparum parasites and showed that the specific PAK-MEK signaling pathway was more highly activated in infected cells than in uninfected cells.
In further experiments, described in the May 1 Science, the scientists discovered that LF inhibits the MAPK signaling pathway by cleaving other proteins that would normally activate MAPK.
These targets are further categorized on the CD-ROM by 29 classifications of molecular function and their possible belonging to 17 different signaling pathways in the cell.
Further research on arsenic stimulation of this important growth signaling pathway is ongoing.
It's much easier [for evolution] to create an inhibitor of a signaling pathway--that is, throw a spanner into the works--than to create a new signaling pathway," he says.
Two families of proteins related to self renewal, the polycomb gene Bmi-1 and the Wnt signaling pathway proteins, have been related to the maintenance of the tumor stem cell phenotype.

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