The Wnt/[beta]-catenin signaling pathway
controls numerous processes in embryonic development, such as the formation of the body axis and of organ primordia, and is particularly active in embryonic and adult stem cells.
Lilly scientists have identified that Lilly's Hedgehog inhibitor is a small molecule antagonist of Smoothened (Smo), a key regulator of the Hh signaling pathway
, binding to it and inhibiting Hh signaling in a human medulloblastoma tumour cell.
sFRP1 is part of a signaling pathway
involving a series of other genes known as the WNT-signaling pathway
Regulation of tumor necrosis factor-alpha in gliome cells by lead and lipopolyseccharide: involvement of common signaling pathway
To see how hedgehog and other signaling pathways
might affect fat development, endocrinologist Jonathan Graff of the University of Texas Southwestern Medical Center in Dallas and his colleagues studied the effects of activating and blocking the hedgehog and other pathways.
Upon execution of the final agreement, the principal goals of the research program will be to advance the functional understanding of an undisclosed UOM protein in neurodegenerative diseases by researching its signaling pathways
Professor Christian Doerig and his colleagues tested red blood cells infected with Plasmodium falciparum parasites and showed that the specific PAK-MEK signaling pathway
was more highly activated in infected cells than in uninfected cells.
In further experiments, described in the May 1 Science, the scientists discovered that LF inhibits the MAPK signaling pathway
by cleaving other proteins that would normally activate MAPK.
These targets are further categorized on the CD-ROM by 29 classifications of molecular function and their possible belonging to 17 different signaling pathways
in the cell.
Further research on arsenic stimulation of this important growth signaling pathway
It's much easier [for evolution] to create an inhibitor of a signaling pathway
--that is, throw a spanner into the works--than to create a new signaling pathway
," he says.
Two families of proteins related to self renewal, the polycomb gene Bmi-1 and the Wnt signaling pathway
proteins, have been related to the maintenance of the tumor stem cell phenotype.