Eva-Maria and Eckhard Mandelkow, too, suspect that MAPK, or some element in the signal transduction pathway
, links these two hallmarks of Alzheimer's disease.
To do that, scientists begin by modeling individual components such as protein networks and signal transduction pathways
The first proof-of-concept demonstration evaluated genes that are directly responsive to tetrachlorodibenzo-p-dioxin (TCDD; a ubiquitous environmental pollutant and known human carcinogen) and their effect on the retinoic acid signal transduction pathway
The interests of the NIEHS focus on detection of intracellular events including gene expression and signal transduction pathway
alterations, and screening or diagnosis of tissue and organ toxicities related to exposures to environmental agents.
Their topics include the discovery of the pathway and its biological functions, physiological roles of the different JNKs, the JNK signal transduction pathway
in Drosophila, and the pathway as a therapeutic target.
The presence of this other heavy metal in the receptor suggested that this may be where cadmium could introduce itself into the signal transduction pathway
HE3235 appears to act by inhibiting the Src signal transduction pathway
The Company presented preliminary data indicating that HE3235 inhibits the Src signal transduction pathway
involved in androgen- and estrogen-driven HRPC.
For the past 10 years he has concentrated on the upstream events in the Ah receptor (AHR) signal transduction pathway
and showing the importance of the PAS domain in binding and dimerization with its partner protein ARNT (AHR nuclear translocator).
Pre-clinical studies were conducted in hepato-stellate cells in vitro and in an experimental NASH CCL4 model, showing that in both systems, the molecular mechanism of action of Namodenoson was conferred by decreased expression levels of the signaling protein phosphoinositol-3-phosphate which controls 3 downstream signal transduction pathways
, the Wnt, NF-kB and alpha-SMA, which control liver inflammation and liver fibrosis.
1) For this reason, signal transduction pathways
are becoming increasingly important as therapeutic targets, particularly in oncology but also in immunology.
The focus is on sensitive live cell imaging analyzes for the actin dynamics and the mobilization and activity of intracellular components of specific signal transduction pathways
using biosensors (eg calcium, Rho-GTPases) on a single cell level.