In the experiments outlined below we utilize multiparameter phosphoflow cytometry to simultaneously quantify the activity of several different elements of the BCR signal transduction
pathway on a single cell basis.
The pathway builder portion of Protein Lounge allows users to create their own signal transduction
And the regulation of glucose metabolism, hormonal regulation and sugar signal are directly related to signal transduction
(Mathieu et al., 2009; Kleinow et al., 2009).
Protein kinase C (PKC) signal transduction
system involved in larval metamorphosis of the barnacle, Balanus amphitrite.
Since the establishment of the CoBRE in Signal Transduction
, WVU faculty members have published approximately 300 scientific journal articles.
These proprietary lipid mediators, termed "Signal Transduction
Modulators" or STMs, have significant pharmaceutical potential for treating regulatory dysfunctions underlying Alzheimer's, Parkinson's, Rosacea, Psoriasis and other diseases.
The gathering, which was organized by the American Association for Cancer Research (AACR) under the title "From the Laboratory to the Clinic", provided an overview of the most cutting-edge cancer research in various fields, including the tumor microenvironment, microRNAs, signal transduction
, and novel therapeutic development.
type II receptor to inhibit the signal transduction
of human TGF-.beta.
By tracking single molecules inside cells, scientists can get a better understanding of events that occur within cells, such as signal transduction
(the conversion, by a cell, of one signal or stimulus to another), crucial for the biomedical and pharmaceutical industries.
Koretzky, MD, PhD, professor of pathology and laboratory medicine and director of the Signal Transduction
Program at Penn's Abramson Family Cancer Research Institute, describes one way in which T cells may develop tolerance to host cells and proteins.
"Bio-Plex phosphoprotein assays built with CST antibody content provide the means for rigorous parallel analysis of signal transduction
pathways," said CST Director of Business Development Christopher Bunder.
TNF-[alpha]-associated signal transduction
has been well characterized.