sickle cell trait

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trait

[trāt]

1. any genetically determined condition; also, the condition prevailing in the heterozygous state of a recessive disorder, as the sickle cell trait.

2. a distinctive behavior pattern.

sickle cell trait the condition, usually asymptomatic, of being heterozygous for hemoglobin S; see also sickle cell.

sick·le cell trait

the heterozygous state of the gene for hemoglobin S in sickle cell anemia.

Farlex Partner Medical Dictionary © Farlex 2012

sickle cell trait

A hereditary condition, usually harmless and without symptoms, in which an individual carries only one mutated hemoglobin gene for sickle cell anemia. The sickle cell trait confers resistance to some forms of fatal malaria.

sickle cell trait

Heterozygosity for HbS seen in 8% of US blacks, up to 30% of African populations Clinical No anemia, normal growth, development, lifespan, slight ↑ in sudden unexplained death; hematuria, splenic infarction. See Sickle cell disease.

References in periodicals archive ?

Becktel, "Clinical Implications of Sickle-Cell Trait and Glucose-6-Phosphate Dehydrogenase Deficiency in Hospitalized Black Male Patients," The New England Journal of Medicine, vol.

Multifactorial Origin of Exertional Rhabdomyolysis, Recurrent Hematuria, and Episodic Pain in a Service Member with Sickle Cell Trait

In the Sergipe maroon community under analysis, three cases of individuals with sickle-cell trait were reported (Table 1).

In Generation III, the sickle-cell trait gene was probably transmitted by the male individual, father of P3 and P4, who is not a permanent resident in the maroon community under study anymore, having divorced the spouse (Figure 1) and began a new marital relationship.

Prevalence of variant hemoglobins and thalassemias in a maroon community in Sergipe, Brazil/Prevalencia de hemoglobinas variantes e talassemia em uma comunidade quilombola em Sergipe, Brasil

The African Americans and the Caucasian race were reported in 93% and 7% of the valuable cases, respectively; whereas the sickle-cell trait was found in 97.7% of patients (Table 2).

Clinical outcome and prognostic factors in renal medullary carcinoma: a pooled analysis from 18 years of medical literature

The sickle-cell trait is associated with enhanced immunoglobulin G antibody responses to Plasmodium falciparum variant surface antigens.

Frequencies of some human genetic markers and their association with Plasmodium falciparum malaria in the Niger Delta, Nigeria

Although the terms "sickle-cell trait" and "sickle-cell anemia" are used interchangeably by many, they cause distinctly different physical conditions.

Just as with sickle-cell trait, the G-6-PD deficiency may cause no symptoms for years, but when an employee with this deficiency is exposed to industrial chemicals such as benzene, nitrosamines, nitrites, and lead, or even to air pollutants, an abnormal degree of red corpuscle destruction may occur.

Genetic testing: medical and legal issues, and DuPont's program

New York's Civil Rights Law covers blind or deaf employees and Florida protects employees who carry the sickle-cell trait. Some local ordinances preclude discharge for various other reasons, such as having AIDS in Austin, Texas, or sexual orientation and preference in San Francisco.

How to avoid wrongful discharge litigation

Black military recruits carrying the abnormal hemoglobin S in their red blood cells are 28 to 40 times more likely to die suddenly during strenuous physical exertion than are recruits without the so-called sickle-cell trait, researchers reported this week.

Sudden death tied to sickle-cell trait

Search terms included 'Plasmodium falciparum', 'merozoite surface protein', 'genetic diversity', 'malaria', 'multiplicity', 'molecular epidemiology', 'sickle-cell trait', 'natural immunity', 'immune response' used in various combinations like 'merozoite surface protein + genetic diversity', 'sickle-cell trait + genetic diversity', 'merozoite surface protein + sickle-cell trait + P.

Genetic diversity in plasmodium falciparum merozoite surface protein 1 and 2 coding genes and its implications in malaria epidemiology: a review of published studies from 1997-2007

The precise mechanism by which sickle-cell trait imparts resistance to malaria is unknown.

Chloroquine prophylaxis associated with high prevalence of Plasmodium falciparum Pfcrt K76T mutation in people with sickle-cell disease in Benin City, Nigeria

On the other hand, old age of his parents and relatives - up to 50 years - means they could very well have carried sickle-cell traits, and could therefore have been highly resistant to malaria.