Q1 had a mutation (Q226L) at the receptor binding site of the HA protein, indicating a higher binding affinity for sialic acid
a2,6, a characteristic of human cell-surface receptors (5).
5] Since sialic acids
are major constituents of glycoproteins and glycolipids, this study is concerned with TSA and/or LBSA levels.
can occur as terminal residues at antennae.
Lung collagen hydroxyproline, uronic acid, hexosamine, serum sialic acid
, [gamma]-glutamyl transpeptidase, vascular endothelial growth factor (VEGF), granulocyte monocyte colony-stimulating factor and other cytokine levels were significantly lowered in the treated group of animals.
The ubiquitous H1N1 and H3N2 flu strains, for example, use the protein hemagglutinin (H) to bind to matching sialic acid
receptors on the surface of a cell before penetrating it, and then use the enzyme neuraminidase (N) to cleave or split these sialic acids
when viral particles are ready to exit and spread the infection.
Total sialic acid
level in urine was found to be increased (normal value: 17-243 [micro]mol/nmol; the result: 6504 [micro]mol/nmol Cr).
335] possesses a higher affinity towards [alpha]2,8-linked sialic acids
(colominic acid), which was evidenced by competence with colominic acid (Figure 1).
This assay measures the sum of the Tf variants containing 0-2 sialic acid
residues relative to the amount of total Tf.
This is the first report, however, of the presence of sialic acids
in crustacean cuticle extracts.
As a physician, Varki had little interest in great ape genetics until his research on sugar molecules called sialic acids
led him in that direction.
Our mission is to provide pure, more effective biotheraputics through the detection, measurement, and elimination of foreign Sialic acids
(Neu5Gc or NGNA) that have been linked to causing chronic inflammation that can lead to disease.
I am very thankful that I and my associates had the opportunity to cooperate with these colleagues on different topics, but always centered around sialic acids
, especially after the First International Sialic Acid
Meeting, Tokyo (1985), organized by Haruo Ogura and Tamio Yamakawa, and the Japanese-German Sialic Acid
Meeting, Berlin (1988), organized by T.