short tandem repeat

(redirected from Short tandem repeats)


A highly polymorphic segment of DNA composed of repetitive stretches of short sequences of 2–6 base pairs of DNA, which serve as genetic markers to track inheritance in families. Microsatellites include dinucleotides, trinucleotides and tetranucleotides, repeated in tandem arrays throughout a genome. The human genome has 50–100,000 microsatellite loci.

short tandem repeat (STR)

short repetitive DNA sequence. The repeat unit is generally 1–13 NUCLEOTIDES in length and the number of repeats varies in different individuals, usually from 5 to 20. The POLYMERASE CHAIN REACTION (PCR) can be used to determine the number of repeats at a LOCUS, by using PRIMERS that anneal either side of the STR, and analysing the size of the resulting PCR product after amplification. Useful for identification of individuals by DNA FINGERPRINTING.Also called microsatellite DNA
References in periodicals archive ?
Los marcadores Short Tandem Repeats (STR) autosomicos se emplean convencionalmente para determinar parentescos.
Recent advances in genotyping bacteria based on DNA insertion and deletions, single nucleotide polymorphisms (SNP) and other polymorphic DNA structures, such as short tandem repeats (STR), have revolutionised our understanding of disease origins and migration as well as drug resistance and its spread.
Analysis of what is called short tandem repeats - which is the pattern of a person's DNA - allows us to build up a profile.
Also called "short tandem repeats," they provide scientists with a way of locating genes.
ABBREVIATIONS: AAFS = American Academy of Forensic Science; CLS = clinical laboratory science; CODIS = combined DNA index system; DNA = deoxyribonucleic acid; FBI = Federal Bureau of Investigation; PCR = polymerase chain reaction; RFLP = restriction fragment length polymorphisms; STR = short tandem repeats; VNTR = variable numbers of tandem repeats.
Mitnik, et al., High-speed analysis of multiplexed short tandem repeats with an electrophoretic microdevice, Electrophoresis 23 (5), 719-726 (2002).
Allele frequencies of 13 short tandem repeats in population samples from the Iberian Peninsula and northern Africa.
In his endeavor to explain short tandem repeats (STRs), the author takes on the unenviable challenge of attempting to write a book for two distinctly different groups of readers: "forensic scientists who wish to gain a better understanding of STRs, and professionals in the law enforcement and legal communities who find it hard to comprehend the complexities of DNA profiling." With this in mind, John M.
Microsatellite analysis showed almost identical short tandem repeats across the isolates, derived from a genetically clonal background.
Detection of lymphocyte chimerism in skin and GI biopsy by amplification of short tandem repeats by PCR.
Characterisation of Short tandem repeats for genotyping Mycobacterium leprae.
Besides SNPs, there are other important classes of polymorphisms, such as VNTRs (variable number of tandem repeats, polymorphic sequence containing 2050 copies of 6-100 bp repeats), STRs (short tandem repeats, a subclass of VNTR in which repeat unit consists of 2-7 bp) and copy number polymorphisms.

Full browser ?