Shine-Dalgarno sequence

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Shine-Dal·gar·no se·quence

(shīn dăl'gahr-nō),

a purine-rich, untranslated region of mRNA upstream from the initiation codon in prokaryotes; assists in aligning the mRNA on the ribosome.

[J. Shine, L. Dalgarno]

Farlex Partner Medical Dictionary © Farlex 2012

Shine-Dalgarno (SD) sequence

a PURINE-rich sequence (5′-AGGAGGU-3′) about six to eight bases UPSTREAM of the start CODON for TRANSLATION, on bacterial mRNA. The sequence is complementary to, and base pairs (see BASE PAIRING with, a sequence near the 3′-end of the 16S ribosomal RNA of the RIBOSOME. It acts as a RIBOSOME BINDING SITE and is important in ribosome alignment for efficient translation. The sequence is named after J Shine and 1 Dalgarno, who discovered it in ESCHERICHIA COLI .

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

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References in periodicals archive ?

A putative ribosome-binding site (Shine-Dalgarno sequence) was located 5 bps upstream from the initiation codon (Shine and Dalgano, 1975).

Cloning and characterization of an endoglucanase gene from Actinomyces sp. Korean native goat 40

The Shine-Dalgarno sequence [2] is a consensus (5'-AAGGAGGU-3') initially characterized in mRNAs of Escherichia coli.

5'-proximal AUG sequences as translation initiation signals on mRNAs in Escherichia coli

They found that proteins made from genes containing particular sequences (referred to technically as Shine-Dalgarno sequences) were produced more slowly than identical proteins made from genes with different but redundant codons.

New Layer of Genetic Information Helps Determine How Fast Proteins Are Produced

Correlations between Shine-Dalgarno sequences and gene features such as predicted expression levels and operon structures.