Shine-Dalgarno sequence


Also found in: Wikipedia.

Shine-Dal·gar·no se·quence

(shīn dăl'gahr-nō),
a purine-rich, untranslated region of mRNA upstream from the initiation codon in prokaryotes; assists in aligning the mRNA on the ribosome.
[J. Shine, L. Dalgarno]
Farlex Partner Medical Dictionary © Farlex 2012

Shine-Dalgarno (SD) sequence

a PURINE-rich sequence (5′-AGGAGGU-3′) about six to eight bases UPSTREAM of the start CODON for TRANSLATION, on bacterial mRNA. The sequence is complementary to, and base pairs (see BASE PAIRING with, a sequence near the 3′-end of the 16S ribosomal RNA of the RIBOSOME. It acts as a RIBOSOME BINDING SITE and is important in ribosome alignment for efficient translation. The sequence is named after J Shine and 1 Dalgarno, who discovered it in ESCHERICHIA COLI .
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
A putative ribosome-binding site (Shine-Dalgarno sequence) was located 5 bps upstream from the initiation codon (Shine and Dalgano, 1975).
The Shine-Dalgarno sequence [2] is a consensus (5'-AAGGAGGU-3') initially characterized in mRNAs of Escherichia coli.
They found that proteins made from genes containing particular sequences (referred to technically as Shine-Dalgarno sequences) were produced more slowly than identical proteins made from genes with different but redundant codons.
Correlations between Shine-Dalgarno sequences and gene features such as predicted expression levels and operon structures.