SHH(redirected from Shhh)
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Related to Shhh: SSSH
SHHA gene on chromosome 7q36 that encodes a protein central in early embryonic patterning and the key inductive signal in patterning of the anterior-posterior limb axis, the ventral somites and the ventral neural tube.
Defects in SHH or in its signalling pathway cause holoprosencephaly, VACTERL syndrome; mutation upstream of SHH disrupts limb patterning and can result in preaxial polydactyly.